【論文】
50 The Antitumor Antibiotic Fostriecin Covalently Binds on Cysteine-269 of the Protein Phosphatase 2A Catalytic Subunit in Cells. Toshifumi Takeuchi, Noriyuki Takahashi, Kazutomo Ishi, Tomoe Kusayanagi, Kouji Kuramochi, Fumio Sugawara. Bioorganic & Medicinal Chemistry, in press
49 Identification of trimannoside-recognizing peptide sequences from a T7 phage display screen using a QCM device.
Kazusa Nishiyama, Yoichi Takakusagi, Tomoe Kusayanagi, Yuki Matsumoto, Shiori Habu, Kouji Kuramochi, Fumio Sugawara, Kengo Sakaguchi, Hideyo Takahashi, Hideaki Natsugari, Susumu Kobayashi.
Bioorganic & Medicinal Chemistry
2009, 17, 195-202
48 Identification of small molecule binding molecules by affinity purification using a specific ligand immobilized on PEGA resin.
Kouji Kuramochi, Yuka Miyano, Yoshihiro Enomoto, Ryo Takeuchi, Kazutomo Ishi, Yoichi Takakusagi, Takeki Saitoh, Keishi Fukudome, Daisuke Manita, Yoshifumi Takeda, Susumu Kobayashi, Kengo Sakaguchi, Fumio Sugawara,
Bioconjugate Chemistry, 2008, 19, 2417-2426.
47 Efficient one-cycle affinity selection of binding proteins or peptides specific for a small-molecule using a T7 phage display pool.
Yoichi Takakusagi, Kouji Kuramochi, Manami Takagi, Tomoe Kusayanagi, Daisuke Manita, Hiroko Ozawa, Kanako Iwakiri, Kaori Takakusagi, Yuka Miyano, Atsuo Nakazaki, Susumu Kobayashi, Fumio Sugawara, Kengo Sakaguchi,
Bioorganic & Medicinal Chemistry
, 2008, 16, 9837-9846
46 Synthesis and biological activities of neoechinulin A derivatives: new aspects of structure-activity relationships for neoechinulin A.
Kouji Kuramochi, Kensuke Ohnishi, Satoshi Fujieda, Mitsuhiro Nakajima, Yoshihiko Saitoh, Nobuo Watanabe, Toshifumi Takeuchi, Atsuo Nakazaki, Fumio Sugawara, Takao Arai, Susumu Kobayashi,

Chemical & Pharmaceutical Bulletin
, 2008, 56, 1738-1743
45 Synthesis of neoechinulin A and its derivatives.
Kouji Kuramochi, Toshiaki Aoki, Atsuo Nakazaki, Shinji Kamisuki, Masahiro Takeno, Kensuke Ohnishi, Kuniaki Kimoto, Nobuo Watanabe, Takashi Kamakura, Takao Arai, Fumio Sugawara, Susumu Kobayashi,
Synthesis
2008, 3810-3818
44 Neoechinulin A protects against MPP+-induced cytotoxicity in PC12 cells.
Yoshihito Kajimura, Toshiaki Aoki, Kouji Kuramochi, Susumu Kobayashi, Fumio Sugawara, Nubuo Watanabe, Takao Arai,
TheJournal of Antibiotics
2008, 68, 330-333.
43 Podophyllotoxin directly binds a hinge domain in E2 of HPV and inhibits an E2/E7 interaction in vitro.
Takeki Saitoh, Kouji Kuramochi, Takahiko Imai, Kei-ichi Takata, Masahide Takehara, Susumu Kobayashi, Kengo Sakaguchi, Fumio Sugawara,

Bioorganic & Medicinal Chemistry
2008, 16, 5815-5825.
42 Syntheses and applications of fluorescent and biotinylated epolactaene derivatives: epolactaene and its derivative induce disulfide formation.
Kouji Kuramochi, Shunsuke Yukizawa, Seiki Ikeda, Takashi Sunoki, Satoshi Arai, Rie Matsui, Akinori Morita, Yoshiyuki Mizushina, Kengo Sakaguchi, Fumio Sugawara, Masahiko Ikekita, Susumu Kobayashi,
Bioorganic & Medicinal Chemistry
2008, 16, 5039-5049
41 Hymenoic acid, a novel specific inhibitor of human DNA polymerase l from a fungus of Hymenochaetaceae sp.
Masayuki Nishida, Noriko Ida, Mao Horio, Toshifumi Takeuchi, Shinji Kamisuki, Hiroshi Murata, Kouji Kuramochi, Fumio Sugawara, Hiromi Yoshida, Yoshiyuki Mizushina,
Bioorganic & Medicinal Chemistry
2008, 16, 5115-5122.
40 Novel azaphilones, kasanosins A and B, which are specific inhibitors of eukaryotic DNA polymerase b and l from Talaromyces sp.
Takuma Kimura, Masayuki Nishida, Kouji Kuramochi, Fumio Sugawara, Hiromi Yoshida, Yoshiyuki Mizushina, Bioorganic & Medicinal Chemistry 2008, 16, 4594-4599.
39 1-Deoxyrubralactone, a novel specific inhibitor of families X and Y of eukaryotic DNA polymerases from a fungal strain derived from sea algae.
Mitsuki, Naganuma, Masayuki Nishida, Kouji Kuramochi, Fumio Sugawara, Hiromi Yoshida, Yoshiyuki Mizushina, Bioorganic & Medicinal Chemistry 2008, 16, 2936-2944.
38 Diallyl sulfides: Selective inhibitors of family X DNA polymerases from garlic (Allium sativum L.).
Masayuki Nishida, Takahiko Hada, Kouji Kuramochi, Hideki Yoshida, Yuko Yonezawa, Isoko Kuriyama, Fumio Sugawara, Hiromi Yoshida, Yoshiyuki Mizushina,
Food Chemistry
2007, 108, 551–560.
37 Chemical properties of fatty acid derivatives as inhibitors of DNA polymerases.
Ryoichi Nakamura*, Ryo Takeuchi*, Kouji Kuramochi*, Yoshiyuki Mizushina*, Chisato Ishimaru, Yoichi Takakusagi, Masaharu Takemura, Susumu Kobayashi, Hiromi Yoshida, Fumio Sugawara, Kengo Sakagichi
Organic& Biomolecular Chemistry 2007, 5, 3912-3921. (* These coauthors equally contribute to this work.)
36 Screening of paclitaxel-binding molecules from a library of random peptides displayed on T7 phage particles using paclitaxel-photoimmobilized resin.
Sota Aoki, Kengo Morohashi, Takashi Sunoki, Kouji Kuramochi, Susumu Kobayashi, Fumio Sugawara
Bioconjugate Chemistry 2007, 18, 1981-1985.
35 Structure-activity relationships of neoechinulin A analogues with cytoprotection against peroxynitrile-induced PC 12 cell death.
Kuniaki Kimoto, Toshiaki, Aoki, Yasushi Shibata, Shinji Kamisuki, Fumio Sugawara, Kouji Kuramochi, Atsuo Nakazaki, Susumu Kobayashi, Kenji Kuroiwa, Nubuo Watanabe, Takao Arai
Journal of Antibiotics
2007, 60, 614-621.
34 Identification of C10 biotinylated camptothecin(CPT-10-B) binding peptides using T7 phage display screen on a QCM device.
Yoichi Takakusagi, Kaori Takakusagi, Kouji Kuramochi, Susumu Kobayashi, Fumio Sakaguchi, Kengo Sakaguchi
Bioorganic & Medicinal Chemistry 2007, 15, 7590-7598.
33 Synthetic Study on Telemerase Inhibitor, D8646-2-6: Synthesis of the Key Intermediate using Sn(OTf)2 or Sc(OTf)3 Mediated Aldol-type Reaction and Stille Coupling.
Akira Kanai, Yoshifumi Takeda, Kouji Kuramochi, Atsuo Nakazaki, Susumu Kobayashi
Chemical & Pharmaceutical Bulletin
, 2007, 55, 495-499.
32 Structure-activity relationship of a glycolipid, sulfoquinovosyl diacylglycerol, with the DNA binding activity of p53.
Hiroshi Iijima, Nobuyuki Kasai, Hiroyuki Chiku, Toshifumi Takeuchi, Kouji Kuramochi, Shinya Hanashima, Susumu Kobayashi, Fumio Sugawara, Kengo Sakaguchi, Hiromi Yoshida, Yoshiyuki Mizushina

International Journal of Molecular Medicine
, 2007, 19, 41-48.
31 Total Synthesis and Stereochemistry of the Antitumor Antibiotic, PD113,271.
Toshifumi Takeuchi, Kouji Kuramochi, Susumu Kobayashi, Fumio Sugawara
Organic Letters
, 2006, 8, 5307-5310.
30 Synthesis and absolute configuration of (+)-pseudodeflectusin: structural revision of aspergione B.
Fumiyo Saito, Kouji Kuramochi, Atsuo Nakazaki, Yoshiyuki Mizushina, Fumio Sugawara, Susumu Kobayashi
European Journal of Organic Chemistry, 2006, 4796-4799.
29 Inhibitory effect of sulfoquinovosyl diacylglycerol on prokaryotic DNA polymerase I activity and cell groth of Escherchia coli.
Tomoyuki Furukawa, Masayuki Nishida, Takahiko Hada, Kouji Kuramochi, Fumio Sugawara, Susumu Kobayashi, Hiroshi Iijima, Hiroaki Shimada, Hiromi Yoshida, Yoshiyuki Mizushina
Journal of Oleo Science
, 2006, in press.
28 Synthesis of plakevulin A and structure-activity relationships of its related compounds against DNA polymerases.
Kouji Kuramochi, Fumiyo Saito, Ryo Takeuchi, Tomohiro Era, Masaharu Takemura, Jun’ichi Kobayashi, Kengo Sakaguchi, Susumu Kobayashi, Fumio Sugawara
Tetrahedron
, 2006, 62, 8006-8015.
27 Total synthesis of (–)-neoechinulin A.
Toshiaki Aoki, Shinji Kamisuki, Masaaki Kimoto, Kensuke Ohnishi, Yoichi Takakusagi, Kouji Kuracmohi, Yoshifumi Takeda, Atsuo Nakazaki, Kenji Kuroiwa, Takashi Ohuchi, Fumio Sugawara, Takao Arai, Susumu Kobayashi
Synlett, 2006, 677-680.
26 Synthetic Studies on Amphidinolide B1.
Amit K. Mandal, John S. Schneekloth, Jr., Kouji Kuramochi, Craig M. Crews

Organic Letters
, 2006, 8, 427-430.
25 Structural relationships of curcumin derivatives binding to the BRCT domain of human DNA polymerase l.
Takeuchi Toshifumi, Tomomi Ishidoh, Hiroshi Iijima, Isoko Kuriyama, Noriko Shimazaki, Osamu Koiwai, Kouji Kuramochi, Susumu Kobayashi, Fumio Sugawara, Hiromi Yoshida, Kengo Sakaguchi, Yoshiyuki Mizushina.
Genes to Cells, 2006, 11, 223-235.
24 5-(Hydroxymethyl)-2-furfural: A selective inhibitor of DNA polymerase l and terminal deoxynucleotidyltransferase.
Yoshiyuki Mizushina, Etsuko Yagita, Kouji Kuramochi, Isoko Kuriyama, Noriko Shimazaki, Osamu Koiwai,Yukinobu Uchiyama, Yuko Yomezawa, Fumio Sugawara, Susumu Kobayashi, Kengo Sakaguchi, Hiromi Yoshida
Archives of Biochemistry and Biophysics
, 2006, 446, 69-76.
23 Apoptosis-inducing Effect of Epolactactaene derivatives on BALL-1 cells.
Kouji Kuramochi, Rie Matsui, Yasuaki Matsubara, Junko Nakai, Takashi Sunoki, Satoshi Arai, Seigo Nagata, Yukitoshi Nagahara, Yoshiyuki, Mizushina, Masahiko Ikekita, Susumu Kobayashi
Bioorganic & Medicinal Chemistry
, 2006, 14, 2151-2161.
22 Monoacetylcurcumin: A new inhibitor of eukaryotic DNA polymerase l and a new ligand for inhibitor-affinity chromatography.
Yoshiyuki Mizushina, Tomomi Ishidoh, Toshifumi Takeuchi, Noriko Shimazaki, Osamu Koiwai, Kouji Kuramochi, Sususmu Kobayashi, Fumio Sugawara, Kengo Sakaguchi, Hiromi Yoshida
Biochemical and Biophysical Research Communications, 2005, 337, 1288-1295.
21 Synthesis of a biotinylated camptothecin derivative and determination of the binding sequence by T7 phage display technology.
Yoichi Takakusagi, Keisuke Ohta, Kouji Kuramochi, Kengo Morohashi, Susumu Kobayashi, Kengo Sakaguchi, Fumio Sugawara
Bioorganic and Medicinal Chemistry Letters
, 2005, 15, 4846-4849.
20 Developing Microcolin A Analogues as Biological Probes.
Amit Mandal, John Hines, Kouji Kuramochi, Craig M. Crews
Bioorganic & Medicinal Chemistry Letters
, 2005, 15, 4043-4047.
19 Structural analysis of epolactaene derivatives as DNA polymerase inhibitors and anti-inflammatory compounds.
Yoshiyuki Mizushina, Kouji Kuramochi, Hiroshi Ikawa, Isoko Kuriyama, Noriko Shimazaki, Masaharu Takemura, Masahiko Oshige, Hiromi Yoshida, Osamu Koiwai, Fumio Sugawara, Susumu Kobayashi, Kengo Sakaguchi
International Journal of Molecular Medicine, 2005, 15, 785-793.
18 Affinity capture of a mammalian DNA polymerase b by inhibitors immobilized to resins used in solid-phase organic synthesis.
Kouji Kuramochi, Tetsuya Haruyama, Ryo Takeuchi, Takashi Sunoki, Madoka Watanabe, Masahiko Oshige, Susumu Kobayashi, Kengo Sakaguchi, Fumio Sugawara
Bioconjugate Chemistry
, 2005, 16, 97-104. 
17 Synthesis of the Proposed Structure of Plakevulin A: Revised Structure of Plakevulin A.
Fumiyo Saito, Ryo Takeuchi, Tomoyuki Kamino, Kouji Kuramochi, Fumio Sugawara, Kengo Sakaguchi, Susumu Kobayashi, Masashi Tsuda, Jun’ichi Kobayashi
Tetrahedron Letters
, 2004, 45, 8069-8071. 
16 Molecular Design of Cholesterols as Inhibitors of DNA Polymerase a.
Masahiko Oshige, Kouji Kuramochi, Keisuke Ohta, Akitsu Ogawa, Hiroki Kuriyama, Fumio Sugawara, Susumu Kobayashi, Kengo Sakaguchi
Journal of Medicinal Chemistry
2004, 47, 4971-4974.
15 Total synthesis of dehydroaltenusin.
Shinji Kamisuki, Shunya Takahashi, Yoshiyuki Muzushina, Shinya Hanashima, Kouji Kuramochi, Susumu Kobayashi, Kengo Sakaguchi, Tadashi Nakata, Fumio Sugawara
Tetrahedron
, 2004, 60, 5695-5700.
14 Taxol derivatives are selective inhibitors of DNA polymerase a.
Masahiko Oshige, Mika Takenouchi, Yasutaro Kato, Sinji Kamisuki, Toshifumi Takeuchi, Kouji Kuramochi, Isamu Shiina, Yoshihito Suenaga, Yo-ichi Kawakita, Kazufumi Kuroda, Noriyuki Sato, Susumu Kobayashi, Fumio Sugawara, Kengo Sakaguchi
Bioorganic & Medicinal Chemistry
, 2004, 12, 2597-2601.
13 Sturucture-activity relationships of epolactaene analogs as DNA polymerase inhibitors.
Kouji Kuramochi, Yoshiyuki Mizushina, Seigo Nagata, Fumio Sugawara, Kengo Sakaguchi, Susumu Kobayashi
Bioorganic & Medicinal Chemistry, 2004, 12, 1983-1989. 
12 Structure-Activity Relationships of Untenone A and its Derivatives for Inhibition of DNA Polymerases.
Fumiyo Saito, Ryo Takeuchi, Tomoyuki Kamino, Kouji Kuramochi, Fumio Sugawara, Kengo Sakaguchi, Susumu Kobayashi
Bioorganic & Medicinal Chemistry Letters
, 2004, 14, 1975-1977.
11 A convergent total synthesis of epolactaene: an application of bridgehead oxiranyl anion strategy.
Kouji Kuramochi, Seigo Nagata, Hideyoshi Itaya, Yasuaki Matsubara, Takashi Sunoki, Hiromi Uchiro, Ken-ichi Takao, Susumu Kobayashi
Tetrahedron
, 2003, 59, 9743-9758.
10 Synthetic study on Indolic Enamides.
Kouji Kuramochi, Yuko Osada, Takeshi Kitahara
Tetrahedron
, 2003, 59, 9447-9454.
9 A Concise Approach to 5-Substituted-4-Pyrones from Kojic Acid.
Tomoyuki Kamino, Kouji Kuramochi, Susumu Kobayashi
Tetrahedron Letters
, 2003, 44, 7349-7351.
8 Synthetic Studies Directed toward the Assembly of the C-Glycoside Fragment of the Telomerase Inhibitor D8646-2-6.
Akira Kanai, Tomoyuki Kamino, Kouji Kuramochi, Susumu Kobayashi
Organic Letters
, 2003, 5, 2837-2839.  
7 A nobel lipid compound, epolactaene, induces apotosis: its action is modulated by its side chain structure
Junko Nakai, Kentaro Kawada, Seigo Nagata, Kouji Kuramochi, Hiromi Uchiro, Susumu Kobayashi, Masahiko Ikekita
Biochimica et Biophysica Acta
1581 (2002) 1-10.
6 A Facile Synthetic Method for Indolic Enamides.
Kouji Kuramochi, Yuko Osada, Takeshi Kitahara
Chemistry Letters
, 2002, No.2, 128-129.
5 Epolactaene, a novel neuritogenic compound in human neuroblastoma cells, selectively inhibits the activities of mammalian DNA polymerases and human DNA topoisomerase II.
Yoshiyuki Mizushina, Susumu Kobayashi, Kouji Kuramochi, Seigo Nagata, Fumio Sugawara, Kengo Sakaguchi
(2000) Biochemical and Biophysical Research Communication 273, 784-788.
4 Synthetic Study on Oximidines: A Concise Synthesis of (Z)-Enamides.
Kouji Kuramochi, Hidenori Watanabe, Takeshi Kitahara
Synlett
, 2000, 397-399.
3 Convergent total synthesis of epolactaene: application of bridgehead oxiranyl anion strategy.
Kouji Kuramochi, Seigo Nagata, Hideyoshi Itaya, Ken-ichi Takao, Susumu Kobayashi
Tetrahedron Letters
, 1999, 40, 7371-7374.
2 Generation and reaction of an oxiranyl anion derived from a,b-epoxy-g-butyrolactone.
Kouji Kuramochi, Hideyoshi Itaya, Seigo Nagata, Ken-ichi Takao, Susumu Kobayashi
Tetrahedron Letters
, 1999, 40, 7367-7370. 
1 On the Stereochemistry of Tethered Intermediates in p-Methoxybenzyl-Assisted b-Mannosylation.
Matthias Lergenmüller, Tomoo Nukada, Koji Kuramochi, Akihito Dan, Tomoya Ogawa, Yukishige Ito
European Journal of Organic Chemistry
, 1999, 1367-1376.
【著書・総説】
2

Study on the Molecular Structure and Bio-Activity (DNA Polymerase Inhibitory Activity, Anti-Inflammatory Activity and Anti Oxidant Activity) Relationship of Curcumin Derivatives.
Yoshiyuki Mizushina, Toshifumi Takeuchi, Kouji Kuramochi, Susumu Kobayashi, Fumio Sugawara, Kengo Sakaguchi, Hiromi Yoshida
Current Bioactive Compounds
2007, 3, 171-177. 

1

天然物と計算科学・ゲノム科学との接点 菅原二三男、倉持幸司 化学と生物Vol. 42, No. 3, 198-204, 2004

倉持 幸司(くらもち こうじ)
准教授
農学博士
Tel/Fax: 075-703-5603

【研究・教育歴】
1997.3 東京理科大学薬学部製薬学科卒業
1999.3 東京理科大学大学院薬学研究科修士課程終了
2002.3 東京大学大学院農学生命科学研究科博士課程終了
2002.4-2004.3 東京理科大学ゲノム創薬研究センターポスドク
2004.3-2005.3 Yale University, Department of Molecular, Cellular, and Developmental Biology
2005.4-2008.3 東京理科大学理工学部応用生命科学科助手
2007.9- 理化学研究所 客員研究員(兼任)
2008.4-京都府立大学大学院生命環境科学研究科准教授

【所属学会】
日本農芸化学会、日本薬学会、日本化学会、有機合成化学協会