◆研究業績◆

(xx) Original Papers (English)
(Jxx) Original Papers (Japanese)
(Rxx) Reviews
(Pxx) Proceedings
(Bxx) Books
(BExx) Books (Editor)
(MPxx) Methods and Protocols
(Oxx) Others

1995


(1)
 Contribution of Hydrophobic Residues to the Stability of Human Lysozyme: Calorimetric Studies and X-ray Structural Analysis of the Five Isoleucine to Valine Mutants
   Kazufumi Takano, Kyoko Ogasahara, Hidetomo Kaneda, Yuriko Yamagata, Satoshi Fujii, Eiko Kanaya, Masakazu Kikuchi, Motohisa Oobatake & Katsuhide Yutani
   J. Mol. Biol. (1995) 254, 62-76.

1996


(2)
 The Structure, Stability, and Folding Process of Amyloidogenic Mutant Human Lysozyme
   Jun Funahashi, Kazufumi Takano, Kyoko Ogasahara, Yuriko Yamagata & Katsuhide Yutani
   J. Biochem. (1996) 120, 1216-1223.

1997


(3)
 Contribution of the Hydrophobic Effect to the Stability of Human Lysozyme: Calorimetric Studies and X-ray Structural Analyses of the Nine Valine to Alanine Mutants
   Kazufumi Takano, Yuriko Yamagata, Satoshi Fujii & Katsuhide Yutani
   Biochemistry (1997) 36, 688-698.

(4)
 Contribution of Water Molecules in the Interior of a Protein to the Conformational Stability
   Kazufumi Takano, Jun Funahashi, Yuriko Yamagata, Satoshi Fujii & Katsuhide Yutani
   J. Mol. Biol. (1997) 274, 132-142.

1998


(5)
 A General Rule for the Relationship between Hydrophobic Effect and Conformational Stability of a Protein: Stability and Structure of a Series of Hydrophobic Mutants of Human Lysozyme
   Kazufumi Takano, Yuriko Yamagata & Katsuhide Yutani
   J. Mol. Biol. (1998) 280, 749-761.

(6)
 Contribution of Hydrogen Bonds to the Conformational Stability of Human Lysozyme: Calorimetry and X-ray Analysis of Six Tyr -> Phe Mutants
   Yuriko Yamagata, Masahiro Kubota, Yohei Sumikawa, Jun Funahashi, Kazufumi Takano, Satoshi Fujii & Katsuhide Yutani
   Biochemistry (1998) 37, 9355-9362.

1999


(7)
 Contribution of Hydrogen Bonds to the Conformational Stability of Human Lysozyme: Calorimetry and X-ray Analysis of Six Ser -> Ala Mutants
   Kazufumi Takano, Yuriko Yamagata, Masahiro Kubota, Jun Funahashi, Satoshi Fujii & Katsuhide Yutani
   Biochemistry (1999) 38, 6623-6629.

(8)
 Contribution of Amino Acid Substitutions at Two Different Interior Positions to the Conformational Stability of Human Lysozyme
   Jun Funahashi, Kazufumi Takano, Yuriko Yamagata & Katsuhide Yutani
   Protein Engng. (1999) 12, 841-850.

(9)
 Contribution of Intra- and Intermolecular Hydrogen Bonds to the Conformational Stability of Human Lysozyme
   Kazufumi Takano, Yuriko Yamagata, Jun Funahashi, Yusaku Hioki, Seiki Kuramitsu & Katsuhide Yutani
   Biochemistry (1999) 38, 12698-12708.

(10) Experimental Verification of the "Stability Profile of Mutant Protein" (SPMP) Data Using Mutant Human Lysozymes
   Kazufumi Takano, Motonori Ota, Kyoko Ogasahara, Yuriko Yamagata, Ken Nishikawa & Katsuhide Yutani
   Protein Engng. (1999) 12, 663-672.

(11) Effect of Foreign N-terminal Residues on the Conformational Stability of Human Lysozyme
   Kazufumi Takano, Kimiko Tsuchimori, Yuriko Yamagata & Katsuhide Yutani
   Eur. J. Biochem. (1999) 266, 675-682.

(R1)
蛋白質立体構造の安定化因子をどのように見積もればよいか
   高野和文、舩橋順、油谷克英
   生物物理 (1999) 39, 92-96.

(R2) Evaluation of Some Factors that Contribute to Conformational Stability of a Protein Using Database of Stability/Structure
   Katsuhide Yutani, Kazufumi Takano & Jun Funahashi
   Old and New Views of Protein Folding (K. Kuwajima & M. Arai, eds.) (1999) pp. 175-184, Elsevier Science, Amsterdam.

2000


(12) Amyloid Protofilament Formation of Hen Egg Lysozyme in Highly Concentrated Ethanol Solution
   Shuichiro Goda, Kazufumi Takano, Yuriko Yamagata, Ryou Nagata, Hideo Akutsu, Saori Maki, Keiichi Namba & Katsuhide Yutani
   Protein Sci. (2000) 9, 381-387.

(13) Effect of Extra N-terminal Residues on the Stability and Folding of Human Lysozyme Expressed in Pichia pastoris
   Shuichiro Goda, Kazufumi Takano, Yuriko Yamagata, Yoshio Katakura & Katsuhide Yutani
   Protein Engng. (2000) 13, 299-307.

(14) Role of Amino Acid Residues at Turns in the Conformational Stability and Folding of Human Lysozyme
   Kazufumi Takano, Yuriko Yamagata & Katsuhide Yutani
   Biochemistry (2000) 39, 8655-8665.

(15) Contribution of Salt Bridges near the Surface of a Protein to the Conformational Stability
   Kazufumi Takano, Kimiko Tsuchimori, Yuriko Yamagata & Katsuhide Yutani
   Biochemistry (2000) 39, 12375-12381.

(16) Role of Surface Hydrophobic Residues in the Conformational Stability of Human Lysozyme at Three Different Positions
   Jun Funahashi, Kazufumi Takano, Yuriko Yamagata & Katsuhide Yutani
   Biochemistry (2000) 39, 14448-14456.

2001


(17) The Stability and Folding Process of Amyloidogenic Mutant Human Lysozymes
   Kazufumi Takano, Jun Funahashi & Katsuhide Yutani
   Eur. J. Biochem. (2001) 268, 155-159.

(18) Are the Parameters of Various Stabilization Factors Estimated from Mutant Human Lysozymes Compatible with Other Proteins?
   Jun Funahashi, Kazufumi Takano & Katsuhide Yutani
   Protein Engng. (2001) 14, 127-134.

(19) Contribution of Polar Groups in the Interior of a Protein to the Conformational Stability
   Kazufumi Takano, Yuriko Yamagata & Katsuhide Yutani
   Biochemistry (2001) 40, 4853-4858.

(20) Role of Non-glycine Residues in Left-handed Helical Conformation for the Conformational Stability of Human Lysozyme
   Kazufumi Takano, Yuriko Yamagata & Katsuhide Yutani
   Proteins (2001) 44, 233-243.

(21) A New Scale for Side Chain Contribution to Protein Stability Based on the Empirical Stability Analysis of Mutant Proteins
   Kazufumi Takano & Katsuhide Yutani
   Protein Engng. (2001) 14, 525-528.

(22) Role of Amino Acid Residues in Left-handed Helical Conformation for the Conformational Stability of a Protein
   Kazufumi Takano, Yuriko Yamagata & Katsuhide Yutani
   Proteins (2001) 45, 274-280.

(R3) Stability and Structure of a Series of Mutant Human Lysozymes
   Kazufumi Takano & Katsuhide Yutani
   Curr. Topics in Peptide & Protein Res. (2001) 4, 1-16.

2002


(23) Positive Contribution of Hydration Structure on the Surface of Human Lysozyme to the Conformational Stability
   Jun Funahashi, Kazufumi Takano, Yuriko Yamagata & Katsuhide Yutani
   J. Biol. Chem. (2002) 277, 21792-21800.

(24) Elongation in a
β-structure Promotes Amyloid-like Fibril Formation of Human Lysozyme
   Shuichiro Goda, Kazufumi Takano, Yuriko Yamagata, Saori Maki, Keiichi Namba & Katsuhide Yutani
   J. Biochem. (2002) 132, 655-661.

(25) Promotion of Large Protein Crystal Growth with Stirring Solution
   Hiroaki Adachi, Kazufumi Takano, Masashi Yoshimura, Yusuke Mori & Takatomo Sasaki
   Jpn. J. Appl. Phys. (2002) 41, L1025-L1027.

(J1)
有機およびタンパク質結晶育成における短光パルスレーザーの効果
   安達宏昭、細川陽一郎、高野和文、常定扶美、増原宏、吉村政志、森勇介、佐々木孝友
   日本結晶成長学会誌 (2002) 29, 445-449.

2003


(26) Buried Water Molecules Contribute to the Conformational Stability of a Protein
   Kazufumi Takano, Yuriko Yamagata & Katsuhide Yutani
   Protein Engng. (2003) 16, 5-9.

(27) Application of a Two-liquid System to Sitting-drop Vapor Diffusion Protein Crystallization
   Hiroaki Adachi, Kazufumi Takano, Masaaki Morikawa, Shigenori Kanaya, Masashi Yoshimura, Yusuke Mori & Takatomo Sasaki
   Acta Cryst. (2003) D53, 194-196.

(28) Application of a Stirring Method to Micro-scale and Vapor Diffusion Protein Crystallization
   Hiroaki Adachi, Kazufumi Takano, Masashi Yoshimura, Yusuke Mori & Takatomo Sasaki
   Jpn. J. Appl. Phys. (2003) 42, L314-L315.

(29) Effective Protein Crystallization Using Crystal Hysteresis
   Hiroaki Adachi, Kazufumi Takano, Masashi Yoshimura, Yusuke Mori & Takatomo Sasaki
   Jpn. J. Appl. Phys. (2003) 42, L384-L385.

(O1)
カルチャーショック、そして新たな取り組みへ
   高野和文
   生産と技術 (2003) 55, 19-21.

(R4)
蛋白質結晶成長における新しい手法とそのメカニズム−結晶工学からのアプローチ−
   安達宏昭 & 高野和文
   熱測定 (2003) 30, 148-149.

(30) Laser Irradiated Growth of Protein Crystal
   Hiroaki Adachi, Kazufumi Takano, Youichiroh Hosokawa, Tsuyoshi Inoue, Yusuke Mori, Hiroyoshi Matsumura, Masashi Yoshimura, Yasuo Tsunaka, Masaaki Morikawa, Shigenori Kanaya, Hiroshi Masuhara, Yasushi Kai & Takatomo Sasaki
   Jpn. J. Appl. Phys. (2003) 42, L798-L800.

(31) The Contribution of Polar Group Burial to Protein Stability is Strongly Context Dependent
   Kazufumi Takano, J. Martin Scholtz, James C. Sacchettini & C. Nick Pace
   J. Biol. Chem. (2003) 278, 31790-31795.

(32) New Practical Technique for Protein Crystallization with Floating and Stirring Methods
   Hiroaki Adachi, Hiroyoshi Matsumura, Kazufumi Takano, Ai Niino, Tsuyoshi Inoue, Masashi Yoshimura, Yusuke Mori & Takatomo Sasaki
   Jpn. J. Appl. Phys. (2003) 42, L1161-L1163.

2004


(33) Two-liquid Hanging-drop Vapor-diffusion Technique of Protein Crystallization
   Hiroaki Adachi, Hiroyoshi Matsumura, Kazufumi Takano, Ai Niino, Tsuyoshi Inoue, Yusuke Mori & Takatomo Sasaki
   Jpn. J. Appl. Phys. (2004) 43, L79-L81.

(34) Protein Crystal Processing Using a Deep-UV Laser
   Hiroshi Kitano, Hiroaki Adachi, Atsutoshi Murakami, Hiroyoshi Matsumura, Kazufumi Takano, Tsuyoshi Inoue, Yusuke Mori, Soichi Owa & Takatomo Sasaki
   Jpn. J. Appl. Phys. (2004) 43, L73-L75.

(35) A Semiautomatic Protein Crystallization System with Preventing Evaporation of Drops and Surface Sensor of Solution
   Hiroaki Adachi, Kazufumi Takano, Hiroyoshi Matsumura, Ai Niino, Takeshi Ishizu, Tsuyoshi Inoue, Yusuke Mori & Takatomo Sasaki
   Jpn. J. Appl. Phys. (2004) 43, L76-L78.

(36) Protein Crystal Growth with a Two-liquid System and Stirring Solution
   Hiroaki Adachi, Kazufumi Takano, Hiroyoshi Matsumura, Tsuyoshi Inoue, Yusuke Mori & Takatomo Sasaki
   J. Synchrotron Rad. (2004) 11, 121-124.

(37) Pre-stirring Promotes Nucleation of Protein Crystals
   Hiroaki Adachi, Ai Niino, Hiroyoshi Matsumura, Kazufumi Takano, Tsuyoshi Inoue, Yusuke Mori & Takatomo Sasaki
   Jpn. J. Appl. Phys. (2004) 43, L243-L246.

(38) New Approach to Improve X-ray Diffraction Pattern of Protein Crystal Using UV-Laser Ablative Processing
   Hiroshi Kitano, Hiroaki Adachi, Atsutoshi Murakami, Hiroyoshi Matsumura, Kazufumi Takano, Tsuyoshi Inoue, Yusuke Mori, Soichi Owa & Takatomo Sasaki
   Jpn. J. Appl. Phys. (2004) 43, L297-L299.

(R5) Amyloidfibrils from the Viewpoint of Protein Folding
   Satoshi Ohnishi & Kazufumi Takano
   Cell. Mol. Life Sci. (2004) 61, 511-524.

(39) Improving the Quality of Protein Crystals Using a Stirring Crystallization
   Hiroaki Adachi, Hiroyoshi Matsumura, Ai Niino, Kazufumi Takano, Takayoshi Kinoshita, Masaichi Warizaya, Tsuyoshi Inoue, Yusuke Mori & Takatomo Sasaki
   Jpn. J. Appl. Phys. (2004) 43, L522-L525.

(40) Possible Involvement of a FKBP Family Protein from a Psychrotrophic Bacterium Shewanella sp. SIB1 in Cold-adaptation
   Yutaka Suzuki, Mitsuru Haruki, Kazufumi Takano, Masaaki Morikawa & Shigenori Kanaya
   Eur. J. Biochem. (2004) 271, 1372-1381.

(B1)
タンパク質の安定性とフォールディング
   高野和文
   ゲノミクス・プロテオミクスの新展開(今中忠行監修)、エヌティーエス出版 (2004) 701-705.

(41) Generation of Protein Crystals Using a Solution-stirring Technique
   Hiroaki Adachi, Ai Niino, Hiroyoshi Matsumura, Kazufumi Takano, Takayoshi Kinoshita, Masaichi Warizaya, Tsuyoshi Inoue, Yusuke Mori & Takatomo Sasaki
   Jpn. J. Appl. Phys. (2004) 43, L762-L764.

(42) The Effects of Solution Stirring on Protein Crystal Growth
   Mari Yaoi, Hiroaki Adachi, Kazufumi Takano, Hiroyoshi Matsumura, Tsuyoshi Inoue, Yusuke Mori & Takatomo Sasaki
   Jpn. J. Appl. Phys. (2004) 43, L686-L688.

(43) Mutational and Structural-based Analyses of the Osmolyte Effect on Protein Stability
   Kazufumi Takano, Minoru Saito, Masaaki Morikawa & Shigenori Kanaya
   J. Biochem. (2004) 135, 701-708.

(44) Universal Processing Technique for Protein Crystals Using a Pulsed UV Laser
   Atsutoshi Murakami, Hiroshi Kitano, Hiroaki Adachi, Hiroyoshi Matsumura, Kazufumi Takano, Tsuyoshi Inoue, Yusuke Mori, Masaaki Doi & Takatomo Sasaki
   Jpn. J. Appl. Phys. (2004) 43, L873-L876.

(R6)
レーザー照射による蛋白質結晶成長制御
   安達宏昭、高野和文、松村浩由、井上豪、森勇介、佐々木孝友
   日本結晶学会誌 (2004) 46, 238-242.

(O2)
創晶プロジェクト
   安達宏昭、松村浩由、村上聡、高野和文、井上豪、森勇介、佐々木孝友
   日本結晶成長学会誌 (2004) 31, 34-35.

(R7)
紫外レーザーを用いた蛋白質結晶の加工
   北野博史、安達宏昭、松村浩由、高野和文、井上豪、森勇介、佐々木孝友
   日本結晶学会誌 (2004) 46, 292-296.

(45) Novel and Simple Screening Techniques of Protein Crystallization by Vapor Diffusion Rate Control
   Hiroaki Adachi, Ai Niino, Hiroyoshi Matsumura, Kazufumi Takano, Tsuyoshi Inoue, Yusuke Mori & Takatomo Sasaki
   Jpn. J. Appl. Phys. (2004) 43, 6264-6267.

(46) Gene Cloning and Biochemical Characterizations of a Thermostable Ribonuclease HIII from Bacillus stearothermophilus
   Hyongi Chon, Rikita Nakano, Naoto Ohtani, Mitsuru Haruki, Kazufumi Takano, Masaaki Morikawa & Sigenori Kanaya
   Biosci. Biotechnol. Biochem. (2004) 68, 2138-2147.

(47) Cleavage of Various Peptides with Pitrilysin from Escherichia coli: Kinetic Analyses Using
β-endorphin and its Derivatives
   Joel Cornista, Satoshi Ikeuchi, Mitsuru Haruki, Atsuko Kohara, Kazufumi Takano, Masaaki Morikawa & Sigenori Kanaya
   Biosci. Biotechnol. Biochem. (2004) 68, 2128-2137.

(48) Application of UV-laser Ablation to Detaching Protein Crystal from Growth Vessel
   Hiroshi Kitano, Hiroaki Adachi, Atsushi Sato, Atsutoshi Murakami, Hiroyoshi Matsumura, Kazufumi Takano, Tsuyoshi Inoue, Yusuke Mori, Masaaki Doi & Takatomo Sasaki
   Jpn. J. Appl. Phys. (2004) 43, L1271-L1274.

(49) Effect of Stirring Method on Protein Crystallization
   Mari Yaoi, Hiroaki Adachi, Kazufumi Takano, Hiroyoshi Matsumura, Tsuyoshi Inoue, Yusuke Mori & Takatomo Sasaki
   Jpn. J. Appl. Phys. (2004) 43, L1318-L1319.

(50) Membrane Protein Crystallization Using Laser Irradiation
   Hiroaki Adachi, Satoshi Murakami, Ai Niino, Hiroyoshi Matsumura, Kazufumi Takano, Tsuyoshi Inoue, Akihito Yamaguchi, Yusuke Mori & Takatomo Sasaki
   Jpn. J. Appl. Phys. (2004) 43, L1376-L1378.
   
(R8)
創晶プロジェクト‐新しいタンパク質結晶育成技術の開発‐
   安達宏昭、新納愛、北野博史、村上聡、高野和文、松村浩由、井上豪、森勇介、佐々木孝友
   構造生物 (2004) 10, 41-58.

(51) Kinetically Robust Monomeric Protein from a Hyperthermophile
   Atsushi Mukaiyama, Kazufumi Takano, Mitsuru Haruki, Masaaki Morikawa & Sigenori Kanaya
   Biochemistry (2004) 43, 13859-13866.

(52) Control of Protein Crystal Nucleation and Growth Using Stirring Solution
   Ai Niino, Hiroaki Adachi, Kazufumi Takano, Hiroyoshi Matsumura, Takayoshi Kinoshita, Masaichi Warizaya, Tsuyoshi Inoue, Yusuke Mori & Takatomo Sasaki
   Jpn. J. Appl. Phys. (2004) 43, L1442-L1444.
   
(R9)
生物工学におけるバイオクリスタルデザインの幕開け
   高野和文
   生物工学会誌 (2004) 82, 552.

(P1) Novel Approach to Process Protein Crystals using Deep-UV Laser
   Hiroshi Kitano, Atsushi Sato, Atsutoshi Murakami, Hiroaki Adachi, Hiroyoshi Matsumura, Kazufumi Takano, Tsuyoshi Inoue, Yusuke Mori, Masaaki Doi & Takatomo Sasaki
   Proceedings of SPIE (2004) 5662, 280-284.

2005


(53) Isolation and Characterization of Rhodococcus sp. TMP2 and T12 that Degrade 2,6,10,14-Tetramethylpentadecane (Pristane) at Moderately Low Temperatures
   Namio Kunihiro, Mitsuru Haruki, Kazufumi Takano, Masaaki Morikawa & Sigenori Kanaya
   J. Biotechnol. (2005) 115, 129-136.

(54) Stabilities and Activitiesof the N- and C-domains of FKBP22 from a Psychrotrophic Bacterium Overproduced in E. coli
   Yutaka Suzuki, Kazufumi Takano & Shigenori Kanaya
   FEBS J. (2005) 272, 632-642.
   
(R10)
バイオクリスタルデザイン
    高野和文、安達宏昭、松村浩由、井上豪、森勇介
    生物物理 (2005) 45, 37-40.

(55) Gene Cloning, Overproduction, and Characterizations of Thermolabile Alkaline Phosphatase from a Psychrotrophic Bacterium
   Yutaka Suzuki, Yoichi Mizutani, Tadao Tsuji, Naoto Ohtani, Kazufumi Takano Mitsuru Haruki, Masaaki Morikawa & Shigenori Kanaya
   Biosci. Biotechnol. Biochem. (2005) 69, 364-373.

(56) Identification of Single Mn2+ Binding Sites Required for Activation of the Mutant Proteins of E. coli RNase HI at Glu48 and/or Asp134 by X-ray Crystallography
   Yasuo Tsunaka, Kazufumi Takano, Hiroyoshi Matsumura, Yuriko Yamagata & Shigenori Kanaya
   J. Mol. Biol. (2005) 345, 1171-1183.

(57) Protein Cryocrystallography Using Laser-processed Crystal
   Hiroshi Kitano, Hiroyoshi Matsumura, Hiroaki Adachi, Satoshi Murakami, Kazufumi Takano, Tsuyoshi Inoue, Yusuke Mori, Soichi Owa & Takatomo Sasaki
   Jpn. J. Appl. Phys. (2005) 44, L54-L56.

(58) Protein Crystallization by Combining Laser Irradiation and Solution Stirring Techniques
   Hiroaki Adachi, Ai Niino, Satoshi Murakami, Kazufumi Takano, Hiroyoshi Matsumura, Takayoshi Kinoshita, Masaichi Warizaya, Tsuyoshi Inoue, Yusuke Mori & Takatomo Sasaki
   Jpn. J. Appl. Phys. (2005) 44, 1365-1366.

(59) Protein Crystal Growth Using Laser-processed Seed Crystals
   Kengo Takeuchi, Hiroshi Kitano, Hiroaki Adachi, Yusuke Mori, Takatomo Sasaki, Hiroyoshi Matsumura, Tsuyoshi Inoue, Satoshi Murakami, Masaaki Doi, Yuichi Koga, Kazufumi Takano & Shigenori Kanaya
   Jpn. J. Appl. Phys. (2005) 44, 3177-3179.

(60) Crystallization and Preliminary X-ray Diffraction Study of Thermostable RNase HIII from Bacillus stearothermophilus
   Hyongi Chon, Hiroyoshi Matsumura, Yuiichi Koga, Kazufumi Takano & Shigenori Kanaya
   Acta Cryst. (2005) F61, 293-295.

(61) Overproduction and Preliminary Crystallographic Study of a Human Kynurenine Aminotransferase II Homologue from Pyrococcus horikoshii OT3
   Hyongi Chon, Hiroyoshi Matsumura, Shoko Shimizu, Nao Maeda, Yuiichi Koga, Kazufumi Takano & Shigenori Kanaya
   Acta Cryst. (2005) F61, 319-321.

(62) Temperature-screening System for Determining Protein Crystallization Conditions
   Hiroaki Adachi, Ai Niino, Kazufumi Takano, Hiroyoshi Matsumura, Satoshi Murakami, Tsuyoshi Inoue, Yusuke Mori & Takatomo Sasaki
   Jpn. J. Appl. Phys. (2005) 44, 4080-4083.
   
(R11)
蛋白質の安定性とそこに秘めるもの
    高野和文
    生産と技術 (2005) 57, 43-45.

(63) Processing of Membrane Protein Crystal Using UV Laser Irradiation
   Hiroshi Kitano, Satoshi Murakami, Hiroaki Adachi, Hiroyoshi Matsumura, Kazufumi Takano, Tsuyoshi Inoue, Yusuke Mori, Soichi Owa & Takatomo Sasaki
   J. Biosci. Bioeng. (2005) 100, 50-53.

(64) Gene Cloning and in vivo Characterization of a Dibenzothiophene Dioxygenase from Xanthobacter polyaromaticivorans
   Shin-ichi Hirano, Mitsuru Haruki, Kazufumi Takano, Tadayuki Imanaka, Masaaki Morikawa & Shigenori Kanaya
   Appl. Microbiol. Biotechnol. (2006) 69, 672-681.

(65) Crystal Structure of a Human Kynurenine Aminotransferase II Homologue from Pyrococcus horikoshii OT3 at 2.20
Å Resolution
   Hyongi Chon, Hiroyoshi Matsumura, Yuiichi Koga, Kazufumi Takano & Shigenori Kanaya
   Proteins (2005) 61, 685-688.

(66) Solution Stirring Initiates Nucleation and Improves the Quality of Adenosine Deaminase Crystals
   Hiroaki Adachi, Kazufumi Takano, Ai Niino, Hiroyoshi Matsumura, Takayoshi Kinoshita, Masaichi Warizaya, Tsuyoshi Inoue, Yusuke Mori & Takatomo Sasaki
   Acta Cryst. (2005) D61, 759-762.

(67) Semiautomatic Protein Crystallization System Featuring Crystallization Solution Preparation Function
   Hiroaki Adachi, Hiroyoshi Matsumura, Tsuyoshi Inoue, Ai Niino, Kazufumi Takano, Satoshi Murakami, Yusuke Mori & Takatomo Sasaki
   Jpn. J. Appl. Phys. (2005) 44, 6302-6303.

(68) Femtosecond Laser Processing of Protein Crystals in Crystallization Drop
   Masafumi Kashii, Hiroshi Kitano, Yoichiroh Hosokawa, Hiroaki Adachi, Yusuke Mori, Takatomo Sasaki, Hiroshi Masuhara, Kazufumi Takano, Hiroyoshi Matsumura, Tsuyoshi Inoue, Satoshi Murakami, Kazuomi Sugamoto & Hideki Yoshikawa
   Jpn. J. Appl. Phys. (2005) 44, L873-L875.

(69) Structural Basis of Compound Recognition by Adenosine Deaminase
   Takayoshi Kinoshita, Isao Nakanishi, Tadashi Terasaka, Masako Kuno, Nobuo Seki, Masaichi Warizaya, Hiroyoshi Matsumura, Tsuyoshi Inoue, Kazufumi Takano, Hiroaki Adachi, Yusuke Mori & Takashi Fujii
   Biochemistry (2005) 44, 10562-10569.

(70) Importance of a Repetitive Nine-residue Sequence Motif for Intracellular Stability and Functional Structure of a Family I.3 Lipase
   Clement Angkawidjaja, Aditya Paul, Yuichi Koga, Kazufumi Takano & Shigenori Kanaya
   FEBS Lett. (2005) 579, 4707-4712.

(71) Effect of Laser Irradiation on Enzyme Activity
   Satoshi Murakami, Masafumi Kashii, Hiroshi Kitano, Hiroaki Adachi, Kazufumi Takano, Hiroyoshi Matsumura, Tsuyoshi Inoue, Yusuke Mori, Masaaki Doi, Kazuomi Sugamoto, Hideki Yoshikawa & Takatomo Sasaki
   Jpn. J. Appl. Phys. (2005) 44, 8216-8218.

(72) Phylogenetic Analysis of Condensation Domain in the Nonribosomal Peptide Synthetases
   Niran Roongsawang, Siew Ping Lim, Kenji Washio, Kazufumi Takano, Shigenori Kanaya & Masaaki Morikawa
   FEMS Microbiol. Lett. (2005) 252, 143-151.

(73) Binding Analysis of a Psychrotrophic FKBP22 to a Folding Intermediate of Protein Using Surface Plasmon Resonance
   Yutaka Suzuki, Ohnmar Ye Win, Yuichi Koga, Kazufumi Takano & Shigenori Kanaya
   FEBS Lett. (2005) 579, 5781-5784.

2006


(74) Amyloidogenecity and Pitrilysin Sensitivity of a Lysine-free Derivative of Amyloid
β-peptide Cleaved from a Recombinant Fusion Protein
   Joel Cornista, Yuichi Koga, Kazufumi Takano, & Shigenori Kanaya
   J. Biotechnol. (2006) 122, 186-197.

(75) Solution-Stirring Method Improves Crystal Quality of Human Triosephosphate Isomerase
   Hiroaki Adachi, Ai Niino, Takayoshi Kinoshita, Masaichi Warizaya, Riyo Maruki, Kazufumi Takano, Hiroyoshi Matsumura, Tsuyoshi Inoue, Satoshi Murakami, Yusuke Mori & Takatomo Sasaki
   J. Biosci. Bioeng. (2006) 101, 83-86.

(76) Structure of Amyloid
β Fragments in Aqueous Environments
   Kazufumi Takano, Shuji Endo, Atsushi Mukaiyama, Hyongi Chon, Hiroyoshi Matsumura, Yuichi Koga & Shigenori Kanaya
   FEBS J. (2006) 273, 150-158.

(77) Crystal Structure and Structure-based Mutational Analyses of RNase HIII from Bacillus stearothermophilus: a New Type 2 RNase H with TBP-like Substrate-binding Domain at the N-terminus
   Hyongi Chon, Hiroyoshi Matsumura, Yuiichi Koga, Kazufumi Takano & Shigenori Kanaya
   J. Mol. Biol. (2006) 356, 165-178.

(78) Effect of Ultrasonic Irradiation on Protein Crystallization
   Keisuke Kakinouchi, Hiroaki Adachi, Hiroyoshi Matsumura, Tsuyoshi Inoue, Satoshi Murakami, Yusuke Mori, Yuichi Koga, Kazufumi Takano & Shigenori Kanaya
   J. Cryst. Growth (2006) 292, 437-440.

(79) Cooling-rate Screening System for Determining Protein Crystal Growth Conditions
   Ryota Murai, Shinya Nakata, Masafumi Kashii, Hiroaki Adachi, Ai Niino, Kazufumi Takano, Hiroyoshi Matsumura, Satoshi Murakami, Tsuyoshi Inoue, Yusuke Mori & Takatomo Sasaki
   J. Cryst. Growth (2006) 292, 433-436.

(80) Crystallization and Preliminary X-ray Analysis of the tRNA Thiolation Enzyme MnmA from Escherichia coli complexed with tRNAGlu
   Tomoyuki Numata, Y. Ikeuchi, Shuya Fukai, Hiroaki Adachi, Hiroyoshi Matsumura, Kazufumi Takano, Satoshi Murakami, Tsuyoshi Inoue, Yusuke Mori, Takatomo Sasaki, T. Suzuki & Osamu Nureki
   Acta Cryst. (2006) F62, 368-371.

(81) Purification, Crystallization and Preliminary X-ray Diffraction of SecDF, a Translocon-Associated Membrane Protein, from Thermus thermophilus
   Tomoya Tsukazaki, Hiroyuki Mori, Shuya Fukai, Tomoyuki Numata, Anna Perederina, Hiroaki Adachi, Hiroyoshi Matsumura, Kazufumi Takano, Satoshi Murakami, Tsuyoshi Inoue, Yusuke Mori, Takatomo Sasaki, Dmitry G. Vassylyev, Osamu Nureki & Koreaki Ito
   Acta Cryst. (2006) F62, 376-380.

(82) Identification of RNase HII from Psychrotrophic Bacterium, Shewanella sp. SIB1 as a High-activity Type RNase H
   Hyongi Chon, Takashi Tadokoro, Naoto Ohtani, Yuichi Koga, Kazufumi Takano & Shigenori Kanaya
   FEBS J. (2006) 273, 2264-2275.

(83) Ca2+-Dependent Maturation of Tk-subtilisin from a Hyperthermophilic Archaeon: Propeptide is a Potent Inhibitor of the Mature Domain but is not Required for Its Folding
   Marian Pulido, Kenji Saito, Shun-ichi Tanaka, Yuichi Koga, Masaaki Morikawa, Kazufumi Takano & Shigenori Kanaya
   Appl. Environ. Microbiol. (2006) 72, 4154-4162.

(84) Extracellular Secretion of E. coli Alkaline Phosphatase with a C-terminal Tag by Type I Secretion System: Purification and Biochemical Characterization
   Clement Angkawidjaja, Katsumasa Kuwahara, Kenji Omori, Yuichi Koga, Kazufumi Takano & Shigenori Kanaya
   Protein Eng. Des. Sel. (2006) 19, 337-343.
   
(R12)
フェムト秒レーザー照射による結晶核発生と溶液攪拌による新しいタンパク質結晶化技術
    森勇介、安達宏昭、高野和文、井上豪、村上聡、松村浩由、佐々木孝友
    OPTRONICS (2006) 25, 201-207.

(85) Crystallization and Preliminary Crystallographic Analysis of Orotidine 5'-monophosphate Decarboxylase from the Human Malaria Parasite Plasmodium falciparum
   Sudaratana R. Krungkrai, Keiji Tokuoka, Yukiko Kusakari, Tsuyoshi Inoue, Hiroaki Adachi, Hiroyoshi Matsumura, Kazufumi Takano, Satoshi Murakami, Yusuke Mori, Yasushi Kai, Jerapan Krungkrai & Toshihiro Horii
   Acta Cryst. (2006) F62, 542-545.

(86) Biofilm Formation by Bacillus subtilis that Produces Gamma-polyglutamate
   Masaaki Morikawa, Shinji Kagihiro, Mitsuru Haruki, Kazufumi Takano, Steve Branda, Roberto Kolter & Shigenori Kanaya
   Microbiology-SGM (2006) 152, 2801-2807.

(87) Crystallization and Preliminary Crystallographic Analysis of Type 1 RNase H from Hyperthermophilic Archaeon Sulfolobus tokodaii 7
   Dong-Ju You, Hyongi Chon, Yuichi Koga, Kazufumi Takano & Shigenori Kanaya
   Acta Cryst. (2006) F62, 781-784.
   
(R13)
創晶プロジェクトとバイオグリッドの連携による創薬開発の試み
    井上豪、門祐示、有竹浩介、松村浩由、甲斐泰、福西快文、中村春木、木下誉富、仲西功、南方聖司、小松満男、 安達宏昭、森勇介、高野和文、村上聡、佐々木孝友、宮野雅司、裏出良博、坂田恒昭
    SAR News (2006) 10, 2-6.

(88) Crystallization and Preliminary X-ray Diffraction Study of Active-site Mutant of Pro-Tk-subtilisin from a Hyperthermophilic Archaeon
   Shun-ichi Tanaka, Kenji Saito, Hyongi Chon, Hiroyoshi Matsumura, Yuichi Koga, Kazufumi Takano & Shigenori Kanaya
   Acta Cryst. (2006) F62, 902-905.

(89) Application of Femtosecond Laser Ablation for Detaching Grown Protein Crystals from a Glass Capillary Tube
   Masafumi Kashii, Ryo Fujisawa, Hiroaki Adachi, Yusuke Mori, Takatomo Sasaki, Yuichi Koga, Kazufumi Takano, Shigenori Kanaya, Hiroyoshi Matsumura, Tsuyoshi Inoue, Satoshi Murakami, Kazuomi Sugamoto & Hideki Yoshikawa
   J. Biosci. Bioeng. (2006) 102, 372-374.
   
(R14)
タンパク質・有機分子の新しい結晶化技術
    安達宏昭、高野和文、森勇介
    ファルマシア (2006) 24, 1237-1240.

(90) A Hyperthermophilic Protein Acquires Function at the Cost of Stability
   Atsushi Mukaiyama, Mitsuru Haruki, Motonori Ota, Yuichi Koga, Kazufumi Takano & Shigenori Kanaya
   Biochemistry (2006) 45, 12673-12679.
   
(R15)
フェムト秒レーザー照射によるタンパク質・有機低分子の結晶化
    安達宏昭、森勇介、佐々木孝友、高野和文、松村浩由、井上豪、村上聡
    酵素工学ニュース (2006) 56, 9-13.
   
(R16)
低温菌由来タンパク質の利用
    古賀雄一、板東敬祐、高野和文、金谷茂則
    実用産業情報 (2006) 39, 20-23.
   
(R17)
枯草菌バイオフィルム形成遺伝子の探索
    森川正章、河合良尚、相原悠、鷲尾健司、高野和文、金谷茂則
    生物工学会誌 (2006) 84, 488-490.

2007


(91) Gentisate 1,2-dioxygenase from Xanthobacter Polyaromaticivorans 127W
   Shin-ichi Hirano, Masaaki Morikawa, Kazufumi Takano, Tadayuki Imanaka & Shigenori Kanaya
   Biosci. Biotechnol. Biochem. (2007) 71, 192-199.

(92) Femtosecond Laser-induced Cleaving of Protein Crystal in Water Solution
   Masafuki Kashii, Yoichiroh Hosokawa, Hiroshi Kitano, Hiroaki Adachi, Yusuke Mori, Kazufumi Takano, Hiroyoshi Matsumura, Tsuyoshi Inoue, Satoshi Murakami, Kazuomi Sugamoto, Hideki Yoshikawa, Takatomo Sasaki & Hiroshi Masuhara
   Appl. Sur. Sci. (2007) 253, 6447-6450.

(P2) Development of Protein Crystallization and Processing: Femtosecond Laser, All Solid-state 193 nm Laser, and Solution Stirring Techniques
   Yusuke Mori, Kazufumi Takano, Hiroaki Adachi, Tsuyoshi Inoue, Satoshi Murakami, Hiroyoshi Matsumura, Masafuki Kashii, Hiroshi Y. Yoshikawa, Syou Maki, Tomoya Kitatani, Shino Okada & Takatomo Sasaki
   Proceedings of SPIE (2007) 6460, 646008.

(93) Crystallization and Preliminary X-ray Diffraction Study of Glycerol Kinase from Hyperthermophilic Archaeon Thermococcus kodakaraensis
   Ryota Katsumi, Yuichi Koga, Dong-Ju You, Hiroyoshi Matsumura, Kazufumi Takano & Shigenori Kanaya
   Acta Cryst. (2007) F63, 126-129.

(94) Directed Evolution of Tk-subtilisin from Hyperthermophilic Archaeon: Identification of Single Amino Acid Substitution Responsible for Low-temperature Adaptation
   Marian Pulido, Yuichi Koga, Kazufumi Takano & Shigenori Kanaya
   Protein Eng. Des. Sel. (2007) 20, 143-153.

(95) Crystal Structure of Unautoprocessed Precursor of Subtilisin from a Hyperthermophilic Archaeon: Evidence for Ca2+-induced Folding
   Shun-ichi Tanaka, Kenji Saito, Hyongi Chon, Hiroyoshi Matsumura, Yuichi Koga, Kazufumi Takano & Shigenori Kanaya
   J. Biol. Chem. (2007) 282, 7825-7832.
   
(R18)
タンパク質光結晶化技術
    安達宏昭、森勇介、佐々木孝友、高野和文、井上豪、松村浩由、村上聡
    光学 (2007) 36, 10-14.

(96) Extracellular Overproduction and Preliminary Crystallographic Analysis of a Family I.3 Lipase
   Clement Angkawidjaja, Dong-Ju You, Hiroyoshi Matsumura, Yuichi Koga, Kazufumi Takano & Shigenori Kanaya
   Acta Cryst. (2007) F63, 187-189.

(97) Conformational Contagion in a Protein: Structural Properties of a Chameleon Sequence
   Kazufumi Takano, Yoshiaki Katagiri, Atsushi Mukaiyama, Hyongi Chon, Hiroyoshi Matsumura, Yuichi Koga & Shigenori Kanaya
   Proteins (2007) 68, 617-625.

(B2)
フェムト秒レーザー照射による結晶核発生と溶液撹拌による新しいタンパク質結晶化技術
   森勇介、安達宏昭、高野和文、井上豪、村上聡、松村浩由、佐々木孝友
   バイオプロセスハンドブック、エヌティーエス出版 (2007) 340-347.

(98) Structural, Thermodynamic, and Mutational Analyses of a Psychrotrophic RNase HI
   Takashi Tadokoro, Dong-Ju You, Yumi Abe, Hyongi Chon, Hiroyoshi Matsumura, Yuichi Koga, Kazufumi Takano & Shigenori Kanaya
   Biochemistry (2007) 46, 7460-7468.

(99) Identification of the Gene Encoding a Type 1 RNase H with an N-terminal Double-Stranded RNA Binding Domain from a Psychrotrophic Bacterium
   Takashi Tadokoro, Hyongi Chon, Yuichi Koga, Kazufumi Takano & Shigenori Kanaya
   FEBS J. (2007) 274, 3715-3727.

(P3) Drug Development Value Chain Constructed by Collaboration Between The SOSHO Project and The NPO BIOGRID
   Tsuyoshi Inoue, Yuji Kado, Keiji Tokuoka, Hiroyoshi Matsumura, Yasushi Kai, Yusuke Mori, Hiroaki Adachi, Kazufumi Takano, Satoshi Murakami, Yoshifumi Fukunishi, Haruki Nakamura, Takayoshi Kinoshita, Isao Nakanishi, Yasushi Okuno, Satoshi Minakata & Tsuneaki Sakata
   AIP Conference Proceedings (2007) 902, 85-88.

(100) Four New Crystal Structures of Tk-subtilisin in Unautoprocessed, Autoprocessed and Mature Forms: Insight in Structural Changes during Maturation Process
   Shun-ichi Tanaka, Hiroyoshi Matsumura, Yuichi Koga, Kazufumi Takano & Shigenori Kanaya
   J. Mol. Biol. (2007) 372, 1055-1069.

(101) Protein Thermostabilization Requires a Fine-tuned Placement of Surface Charged Residues
   Dong-Ju You, Satoshi Fukuchi, Ken Nishikawa, Yuichi Koga, Kazufumi Takano & Shigenori Kanaya
   J. Biochem. (2007) 142, 507-516.

(102) Crystal Structure of Type 1 RNase H from Hyperthermophilic Archaeon Sulfolobus tokodaii: Role of Arg118 and C-terminal Anchoring
   Dong-Ju You, Hyongi Chon, Yuichi Koga, Kazufumi Takano & Shigenori Kanaya
   Biochemistry (2007) 46, 11494-11503.

(103) Structural and Thermodynamic Analyses of Escherichia coli Ribonuclease HI Variant with Quintuple Thermostabilizing Mutations
   Mitsuru Haruki, Masaki Tanaka, Takehiko Motegi, Takashi Tadokoro, Yuichi Koga, Kazufumi Takano & Shigenori Kanaya
   FEBS J. (2007) 274, 5815-5825.

(104) Crystal Structure of a Family I.3 Lipase from Pseudomonas sp. MIS38 in a Closed Conformation
   Clement Angkawidjaja, Dong-Ju You, Hiroyoshi Matsumura, Katsumasa Kuwahara, Yuichi Koga, Kazufumi Takano & Shigenori Kanaya
   FEBS Lett. (2007) 581, 5060-5064.

(105) Requirement of Left-handed Glycine Residue for High Stability of the Tk-subtilisin Propeptide as Revealed by Mutational and Crystallographic Analyses
   Marian Pulido, Shun-ichi Tanaka, Chutima Sringiew, Dong-Ju You, Hiroyoshi Matsumura, Yuichi Koga, Kazufumi Takano & Shigenori Kanaya
   J. Mol. Biol. (2007) 374, 1359-1373.

(R19)
フェムト秒レーザーによるタンパク質結晶化の制御
   吉川洋史、村井良多、牧祥、北谷友也、杉山成、安達宏昭、高野和文、松村浩由、村上聡、井上豪、佐々木孝友、森勇介
   No.RTM-07-40 (2007) 7-11.

(R20)
創薬バリューチェインによるIn silico創薬研究の紹介
   井上豪、安達宏昭、森勇介、高野和文、松村浩由、村上聡、福西快文、中村春木、木下誉富、仲西功、奥野恭史、南方聖司、佐久間俊広、高田俊和、北島正人、福岡良忠、坂田恒昭
   CBI Monograph Series 2007 (2007) 81-85.

2008


(106) Osmolyte Effect on the Stability and Folding of a Hyperthermophilic Protein
   Atsushi Mukaiyama, Yuichi Koga, Kazufumi Takano & Shigenori Kanaya
   Proteins (2008) 71, 110-118.

(107) Effect of Solution Flow Produced by Rotary Shaker on Protein Crystallization
   Ryota Murai, Hiroshi Y. Yoshikawa, Hisato Kawahara, Syou Maki, Shigeru Sugiyama, Tomoya Kitatani, Hiroaki Adachi, Kazufumi Takano, Hiroyoshi Matsumura, Satoshi Murakami, Tsuyoshi Inoue, Takatomo Sasaki & Yusuke Mori
   J. Cryst. Growth (2008) 310, 2168-2172.

(108) Protein Crystallization in a 100 nl Solution with New Stirring Equipment
   Syou Maki, Ryota Murai, Hiroshi Y. Yoshikawa, Tomoya Kitatani, Shinya Nakata, Hisato Kawahara, Hitoshi Hasenaka, Asako Kobayashi, Shino Okada, Shigeru Sugiyama, Hiroaki Adachi, Hiroyoshi Matsumura, Kazufumi Takano, Satoshi Murakami, Tsuyoshi Inoue, Takatomo Sasaki & Yusuke Mori
   J. Synchrotron Rad. (2008) 15, 269-272.

(109) New Technique of Manipulating a Protein Crystal Using Adhesive Material
   Tomoya Kitatani, Shigeru Sugiyama, Hiroyoshi Matsumura, Hiroaki Adachi, Hiroshi Y. Yoshikawa, Syou Maki, Satoshi Murakami, Tsuyoshi Inoue, Yusuke Mori & Kazufumi Takano
   Appl. Phys. Express (2008) 1, 037002.

(110) Hydrophobic Effect on the Stability and Folding of a Hyperthermophilic Protein
   Hongju Dong, Atsushi Mukaiyama, Takashi Tadokoro, Yuichi Koga, Kazufumi Takano & Shigenori Kanaya
   J. Mol. Biol. (2008) 378, 264-272.

(P4) Crystal Structure of Amyloid Beta Fragment
   Kazufumi Takano, Yoshiki Takeda, Dong-Ju You, Atsushi Mukaiyama, Hiroyoshi Matsumura, Yuichi Koga & Shigenori Kanaya
   New Trends in Alzheimer and Parkinson Related Disorders (2008) 153-156.

(111) Crystal Structure of Highly Thermostable Glycerol Kinase from a Hyperthermophilic Archaeon in a Dimeric Form
   Yuichi Koga, Ryota Katsumi, Dong-Ju You, Hiroyoshi Matsumura, Kazufumi Takano & Shigenori Kanaya
   FEBS J. (2008) 275, 2632-2643.

(R21)
膜タンパク質の結晶化技術の新展開及び創薬バリューチェインの紹介
   井上豪、安達宏昭、村上聡、高野和文、松村浩由、森勇介、福西快文、中村春木、木下誉富、仲西功、奥野恭史、南方聖司、下条真司、坂田恒昭
   薬学雑誌 (2008) 128, 497-505.

(R22) Amyloid
β Conformation in Aqueous Environment
   Kazufumi Takano
   Curr. Alzheimer Res. (2008) 5, 540-547.

(R23)
フェムト秒レーザー誘起タンパク質結晶核発生
   森勇介、安達宏昭、高野和文、井上豪、村上聡、松村浩由、吉川洋史
   O plus E (2008) 30, 480-484.

(BE1)
タンパク質結晶の新展開〜新しい育成技術から構造解析・応用研究へ〜
   高野和文(監修)
   シーエムシー出版 (2008)

(B3)
創薬バリューチェインによるIn silico創薬に関する研究
   井上豪、福西快文、中村春木、木下誉富、仲西功、奥野恭史、南方聖司、佐久間俊広、高田俊和、北島正人、 福岡良忠、奥村利幸、安達宏昭、森勇介、高野和文、松村浩由、村上聡、坂田恒昭
   タンパク質結晶の新展開〜新しい育成技術から構造解析・応用研究へ〜、シーエムシー出版 (2008) 230-239.

(112) Remarkable Stabilization of a Psychrotrophic RNase HI by Combination of Thermostabilizing Mutations Identified by Suppressor Mutation Method
   Takashi Tadokoro, Kyoko Matsushita, Yumi Abe, Muhammad Saifur Rohman, Yuichi Koga, Kazufumi Takano & Shigenori Kanaya
   Biochemistry (2008) 47, 8040-8047.

(113) Laser Energy Dependence on Femtosecond Laser-induced Nucleation of Protein
   Hiroshi Y. Yoshikawa, Ryota Murai, Syou Maki, Tomoya Kitatani, Shigeru Sugiyama, Gen Sazaki, Hiroaki Adachi, Tsuyoshi Inoue, Hiroyoshi Matsumura, Kazufumi Takano, Satoshi Murakami, Takatomo Sasaki & Yusuke Mori
   Appl. Phys. A (2008) 93, 911-915.

(MP1)
熱安定性解析:熱量測定
   向山厚、安東菜津美、高野和文
   蛋白質科学会アーカイブ (2008) 1, e039.

(R24)
フェムト秒レーザー核発生と溶液撹拌による新しいタンパク質結晶化技術
   森勇介、安達宏昭、高野和文、井上豪、村上聡、松村浩由
   ケミカルエンジニヤリング (2008) 53, 22-27.

(114) Effect of the Disease-causing Mutations Identified in Human RNase H2 on the Activities and Stabilities of Yeast RNase H2 and Archaeal RNase HII
   Muhammad S. Rohman, Yuichi Koga, Kazufumi Takano, Hyongi Chon, Robert J. Crouch & Shigenori Kanaya
   FEBS J. (2008) 275, 4836-4849.

(R25)
短パルスレーザーによるタンパク質結晶加工
   吉川洋史、村井良多、北谷友也、安達宏昭、高野和文、松村浩由、井上豪、村上聡、佐々木孝友、森勇介
   オプトロニクス (2008) 27, 153-161.

(115) Crystallization and Preliminary X-ray Diffraction Studies of an RNA Aptamer in Complex with the Human IgG Fc Fragment
   Shigeru Sugiyama, Yusuke Nomura, Taiichi Sakamoto, Tomoya Kitatani, Asako Kobayashi, Shin Miyakawa, Yoshinori Takahashi,Hiroaki Adachi, Kazufumi Takano, Satoshi Murakami, Tsuyoshi Inoue, Yusuke Mori, Yoshikazu Nakamura & Hiroyoshi Matsumura
   Acta Cryst. (2008) F64, 942-944.

(116) Crystallization and Preliminary Neutron Diffraction Studies of HIV-1 Protease Cocrystallized with Inhibitor KNI-272
   Hiroyoshi Matsumura, Motoyasu Adachi, Shigeru Sugiyama, Shino Okada, Megumi Yamakami, Taro Tamada, Koushi Hidaka, Yoshio Hayashi, Tooru Kimura, Yoshiaki Kiso, Tomoya Kitatani, Sho Maki, Hiroshi Y. Yoshikawa, Hiroaki Adachi, Kazufumi Takano, Satoshi Murakami, Tsuyoshi Inoue, Ryota Kuroki & Yusuke Mori
   Acta Cryst. (2008) F64, 1003-1006.

(117) Evaluation and Improvement of a Technique to Manipulate Protein Crystals in Solution
   Tomoya Kitatani, Hiroaki Adachi, Shigeru Sugiyama, Hiroyoshi Matsumura, Ryota Murai, Yoshinori Takahashi, Satoshi Murakami, Tsuyoshi Inoue, Yusuke Mori & Kazufumi Takano
   Jpn. J. Appl. Phys. (2008) 47, 8995-8997.

(R26)
超好熱菌由来蛋白質の熱力学的安定化機構
   向山厚、高野和文
   熱測定 (2008) 35, 237-243.

(118) Importance of the Ca2+-binding Sites in the N-catalytic Domain of a Family I.3 Lipase for Activity and Stability
   Katsumasa Kuwahara, Clement Angkawidjaja, Hiroyoshi Matsumura, Yuichi Koga, Kazufumi Takano & Shigenori Kanaya
   Protein Eng. Des. Sel. (2008) 21, 737-744.

(119) Crystal Structure of Tk-subtilisin Folded without Propeptide: Requirement of Propeptide for Acceleration of Folding
   Shun-ichi Tanaka, Yuki Takeuchi, Hiroyoshi Matsumura, Yuichi Koga, Kazufumi Takano & Shigenori Kanaya
   FEBS Lett. (2008) 582, 3875-3878.

(120) Crystallization and Preliminary X-ray Crystallographic Analysis of Ca2+-free Primary Ca2+-sensor of Na+/Ca2+ Exchanger
   Masashi Mima, Chika Kawai, Kumsun Paku, Koji Tomoo, Toshimasa Ishida, Shigeru Sugiyama, Hiroyoshi Matsumura, Tomoya Kitatani, Hiroshi Y. Yoshikawa, Syou Maki, Hiroaki Adachi, Kazufumi Takano, Satoshi Murakami, Tsuyoshi Inoue, Yusuke Mori, Satomi Kita & Takahiro Iwamoto
   Acta Cryst. (2008) F64, 1125-1127.

(R27) Protein Crystallization Using Femtosecond Laser Irradiation and Solution Stirring
   Kazufumi Takano, Hiroshi Y. Yoshikawa, Tomoya Kitatani, Shigeru Sugiyama, Yoshinori Takahashi, Ryota Murai, Syou Maki, Hiroaki Adachi, Hiroyoshi Matsumura, Tsuyoshi Inoue, Satoshi Murakami & Yusuke Mori
   Curr. Topics in Peptide & Protein Res. (2008) 9, 1-9.

2009


(121) Femtosecond Laser-induced Nucleation of Protein in Agarose Gel
   Hiroshi Y. Yoshikawa, Ryota Murai, Shigeru Sugiyama, Gen Sazaki, Tomoya Kitatani, Yoshinori Takahashi, Hiroaki Adachi, Hiroyoshi Matsumura, Satoshi Murakami, Tsuyoshi Inoue, Kazufumi Takano & Yusuke Mori
   J. Cryst. Growth (2009) 311, 956-959.

(122) Proline Effect on the Thermostability and Slow Unfolding of a Hyperthermophilic Protein
   Kazufumi Takano, Ryogo Higashi, Jun Okada, Atsushi Mukaiyama, Takashi Tadokoro, Yuichi Koga & Shigenori Kanaya
   J. Biochem. (2009) 145, 79-85.

(123) Destabilization of Psychrotrophic RNase HI in a Localized Fashion as Revealed by Mutational and X-ray Crystallographic Analyses
   Muhammad S. Rohman, Takashi Tadokoro, Clement Angkawidjaja, Yumi Abe, Hiroyoshi Matsumura, Yuichi Koga, Kazufumi Takano & Shigenori Kanaya
   FEBS J. (2009) 276, 603-613.

(124) Structure of HIV-1 Protease in Complex with Potent Inhibitor KNI-272 Determined by High Resolution X-ray and Neutron Crystallography
   Motoyasu Adachi, Takashi Ohhara, Kazuo Kurihara, Taro Tamada, Eijiro Honjo, Nobuo Okazaki, Shigeki Arai, Yoshinari Shoyama, Kaname Kimura, Hiroyoshi Matsumura, Shigeru Sugiyama, Hiroaki Adachi, Kazufumi Takano, Yusuke Mori, Koushi Hidaka, Tooru Kimura, Yoshio Hayashi, Yoshiaki Kiso & Ryota Kuroki
   Proc. Natl. Acad. Sci. USA (2009) 106, 4641-4646.

(R28) Slow Unfolding of Monomeric Proteins from Hyperthermophiles with Reversible Unfolding
   Atsushi Mukaiyama & Kazufumi Takano
   Int. J. Mol. Sci. (2009) 10, 1369-1385.

(125) Protein Crystallization in Agarose Gel with High Strength: Developing an Automated System for Protein Crystallographic Processes
   Shigeru Sugiyama, Kana Tanabe, Mika Hirose, Tomoya Kitatani, Hiroshi Hasenaka, Yoshinori Takahashi, Hiroaki Adachi, Kazufumi Takano, Satoshi Murakami, Yusuke Mori, Tsuyoshi Inoue & Hiroyoshi Matsumura
   Jpn. J. Appl. Phys. (2009) 48, 075502.

(126) Engineering of Monomeric FKBP22 with PPIase Activity: Importance of a V-Shaped Dimeric Structure for Binding to Protein Substrate
   Cahyo Budiman, Keisuke Bando, Clement Angkawidjaja, Yuichi Koga, Kazufumi Takano & Shigenori Kanaya
   FEBS J. (2009) 276, 4091-4101.

(B4)
X線構造解析による検証
   安達宏昭、高野和文、松村浩由、村上聡、井上豪、森勇介
   コンピューターで薬を創ろう、ケイ・ディー・ネオブック (2009) 71-80.

(127) Femtosecond Laser Processing of Agarose Gel Surrounding Protein Crystals for the Development of an Automated Crystal Capturing System
   Shigeru Sugiyama, Hiroshi Hasenaka, Mika Hirose, Noriko Shimizu, Tomoya Kitatani, Yoshinori Takahashi, Hiroaki Adachi, Kazufumi Takano, Satoshi Murakami, Yusuke Mori, Tsuyoshi Inoue & Hiroyoshi Matsumura
   Jpn. J. Appl. Phys. (2009) 48, 105502.

(128) A Manipulating Tool for Protein Microcrystals in Solution using Adhesive Materials
   Tomoya Kitatani, Hiroaki Adachi, Shigeru Sugiyama, Hiroyoshi Matsumura, Ryota Murai, Yoshinori Takahashi, Satoshi Murakami, Tsuyoshi Inoue, Yusuke Mori & Kazufumi Takano
   Jpn. J. Appl. Phys. (2009) 48, 118001.

(129) Identification of the Interactions Critical for Propeptide-catalyzed Folding of Tk-subtilisin
   Shun-ichi Tanaka, Hiroyoshi Matsumura, Yuichi Koga, Kazufumi Takano & Shigenori Kanaya
   J. Mol. Biol. (2009) 394, 306-319.

(130) Requirement of a Unique Ca2+-binding Loop for Folding of Tk-subtilisin from a Hyperthermophilic Archaeon
   Yuki Takeuchi, Shun-ichi Tanaka, Hiroyoshi Matsumura, Yuichi Koga, Kazufumi Takano & Shigenori Kanaya
   Biochemistry (2009) 48, 10637-10643.

(131) Growth of Large Protein Crystals by Top-seeded Solution Growth Together with Floating and Solution-stirring Technique
   Noriko Shimizu, Shigeru Sugiyama, Mihoko Maruyama, Hiroshi Y. Yoshikawa, Yoshinori Takahashi, Hiroaki Adachi, Kazufumi Takano, Satoshi Murakami, Tsuyoshi Inoue, Hiroyoshi Matsumura & Yusuke Mori
   Cryst. Growth Des. (2009) 9, 5227-5232.

(132) Promotion of Crystal Nucleation of Protein by Semi-solid Agarose Gel
   Kana Tanabe, Mika Hirose, Ryota Murai, Shigeru Sugiyama, Noriko Shimizu, Mihoko Maruyama, Yoshinori Takahashi, Hiroaki Adachi, Kazufumi Takano, Satoshi Murakami, Yusuke Mori, Eiichi Mizohata, Tsuyoshi Inoue & Hiroyoshi Matsumura
   Appl. Phys. Express (2009) 2, 125501.

(133) Femtosecond Laser Processing of Protein Crystals Grown in Agarose Gel
   Hiroshi Hasenaka, Shigeru Sugiyama, Mika Hirose, Noriko Shimizu, Tomoya Kitatani, Yoshinori Takahashi, Hiroaki Adachi, Kazufumi Takano, Satoshi Murakami, Tsuyoshi Inoue, Yusuke Mori & Hiroyoshi Matsumura
   J. Cryst. Growth (2009) 312, 73-78.

2010


(R29)
創薬バリューチェインのインシリコ技術を活用した阻害剤開発の試み
   井上豪、安達宏昭、森勇介、高野和文、松村浩由、村上聡、福西快文、中村春木、木下誉富、仲西功、奥野恭史、南方聖司、佐久間俊広、高田俊和、北島正人、福岡良忠、坂田恒昭
   日本結晶学会誌 (2010) 52, 89-94.

(134) Subtilisin-like Serine Protease from Hyperthermophilic Archaeon Thermococcus kodakaraensis with N- and C-terminal Propeptides
   Tita Foophow, Shun-ichi Tanaka, Yuichi Koga, Kazufumi Takano & Shigenori Kanaya
   Protein Eng. Des. Sel. (2010) 23, 347-355.

(135) Enhancement of Femtosecond Laser-induced Nucleation of Protein in a Gel Solution
   Ryota Murai, Hiroshi Y. Yoshikawa, Yoshinori Takahashi, Mihoko Maruyama, Shigeru Sugiyama, Gen Sazaki, Hiroaki Adachi, Kazufumi Takano, Hiroyoshi Matsumura, Satoshi Murakami, Tsuyoshi Inoue & Yusuke Mori
   Appl. Phys. Lett. (2010) 96, 043702.

(136) Urea Denatured State Ensembles Contain Extensive Secondary Structure that is Increased in Hydrophobic Proteins
   C. Nick Pace, Beatrice M. P. Huyghues-Despointes, Hailong Fu, Kazufumi Takano, J. Martin Scholtz & Gerald R. Grimsley
   Protein Sci. (2010) 19, 929-943.

(137) Cloning of the RNase H Genes from a Metagenomic DNA Library: Identification of a New Type 1 RNase H without a Typical Active-Site Motif
   Eiko Kanaya, Tomoko Sakabe, Nhan Nguyen, Satoshi Koikeda, Yuichi Koga, Kazufumi Takano & Shigenori Kanaya
   J. Appl. Microbiol. (2010) 109, 974-983.

(138) Protein Core Adaptability: Crystal Structures of the Cavity-filling Variants of Escherichia coli RNase HI
   Masaki Tanaka, Hyongi Chon, Clement Angkawidjaja, Yuichi Koga, Kazufumi Takano & Shigenori Kanaya
   Protein Pept. Lett. (2010) 17, 1163-1169.

(139) Molecular Resolution Investigation of Tetragonal Lysozyme(110) Face in Liquid by FM-AFM
   Ken Nagashima, Masayuki Abe, Seizo Morita, Noriaki Oyabu, Kei Kobayashi, Hirofumi Yamada, Masahiro Ohta, Ryohei Kokawa, Ryota Murai, Hiroyoshi Matsumura, Hiroaki Adachi, Kazufumi Takano, Satoshi Murakami, Tsuyoshi Inoue & Yusuke Mori
   J. Vac. Sci. Technol. (2010) B28, C4C11-C4C14.

(140) X-ray Crystallographic and MD Simulation Studies on the Interfacial Activation Mechanism of a Family I.3 Lipase with Two Lids
   Clement Angkawidjaja, Hiroyoshi Matsumura, Yuichi Koga, Kazufumi Takano & Shigenori Kanaya
   J. Mol. Biol. (2010) 400, 82-95.

(141) Growth of Large Protein Crystals by a Large-scale Hanging Drop Method
   Keisuke Kakinouchi, Tsutomu Nakamura, Taro Tamada, Hiroaki Adachi, Shigeru Sugiyama, Mihoko Maruyama, Yoshinori Takahashi, Kazufumi Takano, Satoshi Murakami, Tsuyoshi Inoue, Ryota Kuroki, Yusuke Mori & Hiroyoshi Matsumura
   J. Appl. Cryst. (2010) 43, 937-939.

(142) Crystal Growth Procedure of HIV-1 Protease-inhibitor KNI-272 Complex for Neutron Structural Analysis at 1.9
Å Resolution
   Noriko Shimizu, Shigeru Sugiyama, Mihoko Maruyama, Yoshinori Takahashi, Motoyasu Adachi, Taro Tamada, Koushi Hidaka, Yoshio Hayashi, Tooru Kimura, Yoshiaki Kiso, Hiroaki Adachi, Kazufumi Takano, Satoshi Murakami, Tsuyoshi Inoue, Ryota Kuroki, Yusuke Mori & Hiroyoshi Matsumura
   Cryst. Growth Des. (2010) 10, 2990-2994.

(143) Crystal Structure of a Subtilisin Homologue, Tk-SP, from Thermococcus kodakaraensis: Requirement of a C-terminal
β-jelly Roll Domain for Hyperstability
   Tita Foophow, Shun-ichi Tanaka, Clement Angkawidjaja, Yuichi Koga, Kazufumi Takano & Shigenori Kanaya
   J. Mol. Biol. (2010) 400, 865-877.

(144) Estimated Effects of Silicone Glue on Protein Crystal Growth
   Mihoko Maruyama, Noriko Shimizu, Shigeru Sugiyama, Yoshinori Takahashi, Hiroaki Adachi, Kazufumi Takano, Satoshi Murakami, Tsuyoshi Inoue, Hiroyoshi Matsumura & Yusuke Mori
   J. Cryst. Growth (2010) 312, 2771-2774.

(145) Conformational Plasticity of RNA for Target Recognition as Revealed by the 2.15
Å Crystal Structure of a Human IgG-aptamer Complex
   Yusuke Nomura, Shigeru Sugiyama, Taiichi Sakamoto, Shin Miyakawa, Hiroaki Adachi, Kazufumi Takano, Satoshi Murakami, Tsuyoshi Inoue, Yusuke Mori, Yoshikazu Nakamura & Hiroyoshi Matsumura
   Nucleic Acids Res. (2010) 38, 7822-7829.

(146) Evolution and Thermodynamics of Slow Unfolding of Hyperstable Monomeric Proteins
   Jun Okada, Tomohiro Okamoto, Atsushi Mukaiyama, Takashi Tadokoro, Dong-Ju You, Hyongi Chon, Yuichi Koga, Kazufumi Takano & Shigenori Kanaya
   BMC Evol. Biol. (2010) 10, 207.

(147) Importance of an N-terminal Hybrid Binding Domain for Substrate Binding and Mg2+-dependent Activity of RNase HI from Thermotoga maritima
   Nujarin Jongruja, Dong-Ju You, Eiko Kanaya, Yuichi Koga, Kazufumi Takano & Shigenori Kanaya
   FEBS J. (2010) 277, 4474-4489.

(P5) Localization of the HOXC Homeobox Gene Family During Palate Formation in Mice
   Azumi Hirata, Takehito Tsuji, Hideto Imura, Tomohiro Yamada, Takaaki Ueno, Katsuaki Mishima, Nagato Natsume, Toshio Sugahara, Yuichi Koga, Kazufumi Takano & Hiroaki Nakamura
   XX Congress of the EACMFS (2010) 415-420.

2011


(B5) Folding and Unfolding of Hyperthermophilic Proteins; Molecular Basis of Adaptation to Hot Environment
   Atsushi Mukaiyama & Kazufumi Takano
   Protein Folding (E. C. Walters, ed.) (2011) pp. 443-464, Nova Science, Hauppauge (NY).

(148) Flavobacterium banpakuense sp. nov. Isolated from Leaf-and-branch Compost
   Joong-Jae Kim, Hyun Mi Jin, Hyo Jung Lee, Che Ok Jeon, Eiko Kanaya, Yuichi Koga, Kazufumi Takano & Shigenori Kanaya
   Int. J. Syst. Evol. Microbiol. (2011) 61, 1595-1600.

(149) Crystal Structure of Stable Protein, CutA1, from Psychrotrophic Bacterium Shewanella sp. SIB1
   Aya Sato, Sonoko Yokotani, Takashi Tadokoro, Shun-ichi Tanaka, Clement Angkawidjaja, Yuichi Koga, Kazufumi Takano & Shigenori Kanaya
   J. Synchrotron Rad. (2011) 18, 6-10.

(150) Approach for Growth of High-quality and Large Protein Crystals
   Hiroyoshi Matsumura, Shigeru Sugiyama, Mika Hirose, Keisuke Kakinouchi, Mihoko Maruyama, Ryota Murai, Hiroaki Adachi, Kazufumi Takano, Satoshi Murakami, Yusuke Mori & Tsuyoshi Inoue
   J. Synchrotron Rad. (2011) 18, 16-19.

(151) Laser-induced Nucleation in Protein Crystallization: Local Increase in Protein Concentration Induced by Femtosecond Laser Irradiation
   Natsuko Iefuji, Ryota Murai, Mihoko Maruyama, Yoshinori Takahashi, Shigeru Sugiyama, Hiroaki Adachi, Hiroyoshi Matsumura, Satoshi Murakami, Tsuyoshi Inoue, Yusuke Mori, Yuichi Koga, Kazufumi Takano & Shigenori Kanaya
   J. Cryst. Growth (2011) 318, 741-744.

(152) Inhibition of Chymotrypsin- and Subtilisin-like Serine Proteases with Tk-serpin from Hyperthermophilic Archaeon Thermococcus kodakaraensis
   Shun-ichi Tanaka, Yuichi Koga, Kazufumi Takano & Shigenori Kanaya
   Biochim. Biophys. Acta (2011) 1814, 299-307.

(153) Effect of Evaporation on Protein Crystals Grown in Semi-solid Agarose Hydrogel
   Shigeru Sugiyama, Mika Hirose, Noriko Shimizu, Mayumi Niiyama, Mihoko Maruyama, Gen Sazaki, Ryota Murai, Hiroaki Adachi, Kazufumi Takano, Satoshi Murakami, Tsuyoshi Inoue, Yusuke Mori & Hiroyoshi Matsumura
   Jpn. J. Appl. Phys. (2011) 50, 025502.

(154) Importance of an Extreme C-terminal Motif of a Family I.3 Lipase for Stability
   Katsumasa Kuwahara, Clement Angkawidjaja, Yuichi Koga, Kazufumi Takano & Shigenori Kanaya
   Protein Eng. Des. Sel. (2011) 24, 411-418.

(155) Stabilization by Fusion to the C-terminus of Hyperthermophile Sulfolobus tokodaii RNase HI: A Possibility of Protein Stabilization Tag
   Kazufumi Takano, Tomohiro Okamoto, Jun Okada, Shun-ichi Tanaka, Clement Angkawidjaja, Yuichi Koga & Shigenori Kanaya
   PLoS ONE (2011) 6, e16226.

(R30)
結晶成長の新技術
   松村浩由、杉山成、安達宏昭、高野和文、村上聡、井上豪、森勇介
   バイオインダストリー (2011) 28, 30-36.

(B6) Delineation of the Conformational Thermostability of Hyperthermophilic Proteins Based on Structural and Biophysical Analyses
   Atsushi Mukaiyama & Kazufumi Takano
   Thermostable Proteins: Structural Stability and Design (S. Sen & L. Nilsson, eds.) (2011) pp. 1-20, CRC Press, Boca Raton (FL).

(156) An Alternative Mature Form of Subtilisin Homologue, Tk-SP, from Thermococcus kodakaraensis Identified in the Presence of Ca2+
   Nitat Sinsereekul, Tita Foophow, Mai Yamanouchi, Yuichi Koga, Kazufumi Takano & Shigenori Kanaya
   FEBS J. (2011) 278, 1901-1911.

(157) Growth of Protein Crystals by Syringe-type Top-seeded Solution Growth
   Hiroyoshi Matsumura, Keisuke Kakinouchi, Tsutomu Nakamura, Shigeru Sugiyama, Mihoko Maruyama, Hiroaki Adachi, Kazufumi Takano, Satoshi Murakami, Tsuyoshi Inoue & Yusuke Mori
   Cryst. Growth Des. (2011) 11, 1486-1492.

(158) High-resolution Structure of Exo-arabinanase from Penicillium chrysogenum
   Yuri Sogabe, Tomoya Kitatani, Asako Yamaguchi, Takayoshi Kinoshita, Hiroaki Adachi, Kazufumi Takano, Tsuyoshi Inoue, Yusuke Mori, Hiroyoshi Matsumura, Tatsuji Sakamoto & Toshiji Tada
   Acta Cryst. (2011) D67, 415-422.

(159) Influence of Energy and Wavelength on Femtosecond Laser-induced Nucleation of Protein
   Ryota Murai, Hiroshi Y. Yoshikawa, Hitoshi Hasenaka, Yoshinori Takahashi, Mihoko Maruyama, Shigeru Sugiyama, Hiroaki Adachi, Kazufumi Takano, Hiroyoshi Matsumura, Satoshi Murakami, Tsuyoshi Inoue & Yusuke Mori
   Chem. Phys. Lett. (2011) 510, 139-142.

(160) Identification of the Substrate Binding Site in the N-terminal TBP-like Domain of RNase H3
   Seiko Miyashita, Takashi Tadokoro, Clement Angkawidjaja, Dong-Ju You, Yuichi Koga, Kazufumi Takano & Shigenori Kanaya
   FEBS Lett. (2011) 585, 2313-2327.

(161) Crystal Sstructure of N-domain of FKBP22 from Shewanella sp. SIB1: Dimer Dissociation by Disruption of Val-Leu Knot
   Cahyo Budiman, Clement Angkawidjaja, Hideki Motoike, Yuichi Koga, Kazufumi Takano & Shigenori Kanaya
   Protein Sci. (2011) 20, 1755-1764.

(R31) FK506-binding Protein 22 from a Psychrophilic Bacterium, a Cold Shock-inducible Peptidyl Prolyl Isomerase with the Ability to Assist in Protein Folding
   Cahyo Budiman, Yuichi Koga, Kazufumi Takano & Shigenori Kanaya
   Int. J. Mol. Sci. (2011) 12, 5261-5284.

(R32) Folding and Unfolding of Hyperthermophilic Proteins; Molecular Basis of Adaptation to Hot Environment
   Atsushi Mukaiyama & Kazufumi Takano
   Proteomics Res. J. (2011) 1, 203-222.

(R33)
フェムト秒レーザー誘起キャビテーションバブルによるタンパク質の結晶核発生
   吉川洋史、村井良多、杉山成、安達宏昭、松村浩由、井上豪、村上聡、高野和文、森勇介
   日本結晶成長学会誌 (2011) 38, 161-168.

(162) Crystallization and Preliminary X-ray Crystallographic Analysis of a Helicase-like Domain from a Tomato Mosaic Virus Replication Protein
   Hongyu Xiang, Mayumi Niyama, Shigeru Sugiyama, Hiroaki Adachi, Kazufumi Takano, Satoshi Murakami, Tsuyoshi Inoue, Yusuke Mori, Masayuki Ishikawa, Hiroyoshi Matsumura & Etsuko Katoh
   Acta Cryst. (2011) F67, 1649-1652.

2012


(163) Flavobacterium compostarboris sp. nov., Isolated from Leaf-and-branch Compost and Emended Descriptions of Flavobacterium hercynium, Flavobacterium resistens and Flavobacterium johnsoniae
   Joong-Jae Kim, Eiko Kanaya, Hang-Yeon Weon, Yuichi Koga, Kazufumi Takano, Peter F. Dunfield, Soon-Wo Kwon & Shigenori Kanaya
   Int. J. Syst. Evol. Microbiol. (2012) 62, 2018-2024.

(B7) A Stable Protein; CutA1
   Azumi Hirata, Aya Sato, Takashi Tadokoro, Yuichi Koga, Shigenori Kanaya & Kazufumi Takano
   Protein Structure (E. Faraggi, ed.) (2012) pp. 249-262, InTech, Rijeka (Croatia).

(164) Isolation of a Novel Cutinase Homolog with Polyethylene Terephthalate Degrading Activity from Leaf-branch Compost Using a Metagenomic Approach
   Sintawee Sulaiman, Saya Yamato, Eiko Kanaya, Joong-Jae Kim, Yuichi Koga, Kazufumi Takano & Shigenori Kanaya
   Appl. Environ. Microbiol. (2012) 78, 1556-1562.

(165)
Activity, Stability, and Structure of Metagenome-derived LC11-RNase H1, a Homolog of Sulfolobus tokodaii RNase H1
   Tri-Nhan Nguyen, Clement Angkawidjaja, Eiko Kanaya, Yuichi Koga, Kazufumi Takano & Shigenori Kanaya
   Protein Sci. (2012) 21, 553-561.

(166) Growth of Protein Crystals in Hydrogels Prevents Osmotic Shock
   Shigeru Sugiyama, Mihoko Maruyama, Gen Sazaki, Mika Hirose, Hiroaki Adachi, Kazufumi Takano, Satoshi Murakami, Tsuyoshi Inoue, Yusuke Mori & Hiroyoshi Matsumura
   J. Am. Chem. Soc. (2012) 134, 5786-5789.

(167)
Effects of a Forced Solution Flow on the Step Advancement on {110} Faces of Tetragonal Lysozyme Crystals: Direct Visualization of Individual Steps under a Forced Solution Flow
   Mihoko Maruyama, Hisato Kawahara, Gen Sazaki, Shou Maki, Yoshinori Takahashi, Hiroshi Yoshikawa, Shigeru Sugiyama, Hiroaki Adachi, Kazufumi Takano, Hiroyoshi Matsumura, Tsuyoshi Inoue, Satoshi Murakami & Yusuke Mori
   Cryst. Growth Des. (2012) 12, 2856-2863.

(168) Requirement of Ca2+ Ions for Hyperthermostability of Tk-subtilisin from Thermococcus kodakarensis
   Ryo Uehara, Yuki Takeuchi, Shun-ichi Tanaka, Kazufumi Takano, Yuichi Koga & Shigenori Kanaya
   Biochemistry (2012) 51, 5369-5378.

(169) Characteristic Features of Kynurenine Aminotransferase Allosterically Regulated by
α-ketoglutarate in Cooperation with Kynurenine
   Ken Okada, Clement Angkawidjaja, Yuichi Koga, Kazufumi Takano & Shigenori Kanaya
   PLoS ONE (2012) 7, e40307.

(170) Structure and Stability of a Thermostable Carboxylesterase from the Thermoacidophilic Archaeon Sulfolobus tokodaii
   Clement Angkawidjaja,  Yuichi Koga, Kazufumi Takano & Shigenori Kanaya
   FEBS J. (2012) 279, 3071-3084.

(171)
Spatially Precise, Soft Microseeding of Single Protein Crystals by Femtosecond Laser Ablation
   Hiroshi Yoshikawa, Yoichiroh Hosokawa, Ryota Murai, Gen Sazaki, Tomoya Kitatani, Hiroaki Adachi, Tsuyoshi Inoue, Hiroyoshi Matsumura, Kazufumi Takano, Satoshi Murakami, Seiichiro Nakabayashi, Yusuke Mori & Hiroshi Masuhara
   Cryst. Growth Des. (2012) 12, 4334-4339.

(172) Requirement of Insertion Sequence IS1 for Thermal Adaptation of Pro-Tk-subtilisin from Hyperthermophilic Archaeon
   Ryo Uehara, Shun-ichi Tanaka, Kazufumi Takano, Yuichi Koga & Shigenori Kanaya
   Extremophiles (2012) 16, 841-851.

(R34)
固相ハイドロゲル中でのタンパク質結晶化
   杉山成、松村浩由、丸山美帆子、佐崎元、廣瀬未果、安達宏昭、高野和文、村上聡、井上豪、森勇介
   日本結晶学会誌 (2012) 54, 300-303.

(173) Slow Unfolding Pathway of the Hyperthermophilic Tk-RNase H2 Examined by Pulse Proteolysis Using the Stable Protease Tk-subtilisin
   Jun Okada, Yuichi Koga, Kazufumi Takano & Shigenori Kanaya
   Biochemistry (2012) 51, 9178-9191.

2013


(B8) Human Lysozyme Amyloid from the Viewpoint of Protein Folding
   Kanako Shima & Kazufumi Takano
   Lysozymes: Sources, Functions and Role in Disease (X. G. Maang & W. F. Cheung, eds.) (2013) pp. 227-239, Nova Science, Hauppauge (NY).

(174) Heparanase Localization during Palatogenesis in Mice
   Azumi Hirata, Kentaro Katayama, Takehito Tsuji, Nagato Natsume, Toshio Sugahara, Yuichi Koga, Kazufumi Takano, Yoshinori Otsuki & Hiroaki Nakamura
   BioMed Res. Int. (2013) 2013, 760236.

(175) A Test for Stabilization of an Oligomeric Protein by Introduction of Aromatic Residues into the Interface
   Yuho Mano, Ayako Shiota, Kotaro Hara, Azumi Hirata, Masayuki Oda & Kazufumi Takano
   J. Life Sci. (2013) 7, 353-357.

(176) Enzymatic Activity of a Subtilisin Homolog, Tk-SP, from Thermococcus kodakarensis in Detergents and Its Ability to Degrade the Abnormal Prion Protein
   Azumi Hirata, Yuki Hori, Yuichi Koga, Jun Okada, Akikazu Sakudo, Kazuyoshi Ikuta, Shigenori Kanaya & Kazufumi Takano
   BMC Biotechnol. (2013) 13, 19.

(177)
Effects of Gel-solution Interfaces on Femtosecond Laser-induced Nucleation of Protein
   Satoshi Nakayama, Hiroshi Y. Yoshikawa, Ryota Murai, Masateru Kurata, Mihoko Maruyama, Shigeru Sugiyama, Yusuke Aoki, Yoshinori Takahashi, Masashi Yoshimura, Seiichiro Nakabayashi, Hiroaki Adachi, Hiroyoshi Matsumura, Tsuyoshi Inoue, Kazufumi Takano, Satoshi Murakami & Yusuke Mori
   Cryst. Growth Des. (2013) 13, 1491-1496.

(178) Investigating the Structural Dependence of Protein Stabilization by Amino Acid Substitution
   Takashi Tadokoro, Hirotaka Kazama, Yuichi Koga, Kazufumi Takano & Shigenori Kanaya
   Biochemistry (2013) 52, 2839-2847.

(179)
A Novel Approach for Protein Crystallization by a Synthetic Hydrogel with Thermoreversible Gelation Polymer
   Shigeru Sugiyama, Noriko Shimizu, Gen Sazaki, Mika Hirose, Yoshinori Takahashi, Mihoko Maruyama, Hiroyoshi Matsumura, Hiroaki Adachi, Kazufumi Takano, Satoshi Murakami, Tsuyoshi Inoue & Yusuke Mori
   Cryst. Growth Des. (2013) 13, 1899-1904.

(R35)
溶液流れ下におけるタンパク質の結晶成長
   丸山美帆子、中村真利子、佐崎元、高橋義典、吉村政志、吉川洋史、杉山成、安達宏昭、松村浩由、井上豪、高野和文、村上聡、森勇介
   日本結晶成長学会誌 (2013) 40, 72-82.

(180)
Expression, Purification, Crystallization, and Preliminary Crystallographic Analysis of Spermidine Acetyltransferase from Escherichia coli
   Mayumi Niiyama, Shigeru Sugiyama, Mika Hirose, Sae Ishikawa, Hideyuki Tomitori, Kyohei Higashi, Tomoko Yamashita, Hiroaki Adachi, Kazufumi Takano, Satoshi Murakami, Michio Murata, Tsuyoshi Inoue, Yusuke Mori, Keiko Kashiwagi, Hiroyoshi Matsumura & Kazuei Igarashi
   Acta Cryst. (2013) F69, 884-887.

(181) Evolvability of Thermophilic Proteins from Archaea and Bacteria
   Kazufumi Takano, Atsushi Aoi, Yuichi Koga & Shigenori Kanaya
   Biochemistry (2013) 52, 47744780.

(B9)
タンパク質結晶の新展開から最前線へ
   高野和文
   タンパク質結晶の最前線、シーエムシー出版 (2013) 1-7.

(B10)
クリスタルキャッチャーの開発
   高野和文
   タンパク質結晶の最前線、シーエムシー出版 (2013) 149-153.


2014

(182) Proteolysis of Abnormal Prion Protein with a Thermostable Protease from Thermococcus kodakarensis KOD1
   Yuichi Koga, Shun-ichi Tanaka, Akikazu Sakudo, Minoru Tobiume, Mutsuo Aranishi, Azumi Hirata, Kazufumi Takano, Kazuyoshi Ikuta & Shigenori Kanaya
   Appl. Microbiol. Biotechnol. (2014) 98, 2113-2120.

(183)
Strategy for Cold Adaptation of the Tryptophan Synthase α Subunit from the Psychrophile Shewanella frigidimarina K14-2: Crystal Structure and Physicochemical Properties
   Daisuke Mitsuya, Shun-ichi Tanaka, Hiroyoshi Matsumura, Naoto Urano, Kazufumi Takano, Kyoko Ogasahara, Michiyo Takehira, Katsuhide Yutani & Masami Ishida
   J. Biochem. (2014) 155, 73-82.

(R36) Laser Ablation for Protein Crystal Nucleation and Seeding
   Hiroshi Y. Yoshikawa, Ryota Murai, Hiroaki Adachi, Shigeru Sugiyama, Mihoko Maruyama, Yoshinori Takahashi, Kazufumi Takano, Hiroyoshi Matsumura, Tsuyoshi Inoue, Satoshi Murakami, Hiroshi Masuhara & Yusuke Mori
   Chem. Soc. Rev. (2014) 43, 2147-2158.

(184) Contribution of Hydrogen Bonds to Protein Stability
   C. Nick Pace, Hailong Fu, Katrina L. Fryar, John Landua, Saul R. Trevino, David Schell, Richard L. Thurlkill, Satoshi Iimura, J. Martin Scholtz, Ketan Gajiwala, Jozef Sevcik, Lubica Urbanikova, Jeffery K. Myers, Kazufumi Takano, Eric J. Hebert, Bret A. Shirley & Gerald R. Grimsley
   Protein Sci. (2014) 23, 652-661.

(185) A New Practical Technique for High Quality Protein Crystallization with the Solution Stirring Technique at the Interface between High-concentrated Hydrogel and Solution
   Yusuke Aoki, Mihoko Maruyama, Yoshinori Takahashi, Masashi Yoshimura, Hiroshi Y. Yoshikawa, Shigeru Sugiyama, Hiroaki Adachi, Kazufumi Takano, Satoshi Murakami, Hiroyoshi Matsumura, Tsuyoshi Inoue & Yusuke Mori
   Jpn. J. Appl. Phys. (2014) 53, 065502.

(186)
Crystallization and Preliminary Crystallographic Studies of PotA, a Membrane-associated ATPase of the Spermidine-preferential Uptake System in Thermotoga maritima
   Shigeru Sugiyama, Keiko Kashiwagi, Keisuke Kakinouchi, Hideyuki  Tomitori, Ken Kanai, Michio Murata, Hiroaki Adachi, Hiroyoshi Matsumura, Kazufumi Takano, Satoshi Murakami, Tsuyoshi Inoue, Yusuke Mori & Kazuei Igarashi
   Acta Cryst. (2014) F70, 738-741.

(B11)
タンパク質の安定性研究と構造解析
   高野和文
   日本の結晶学(II)−その輝かしい発展−、日本結晶学会 (2014) 389.


2015

(187)
Preliminary X-ray Analysis of the Binding Domain of the Soybean Vacuolar Sorting Receptor Complexed with a Sorting Determinant of a Seed Storage Protein
   Nobuyuki Maruyama, Tomohiro Goshi, Shigeru Sugiyama, Mayumi Niiyama, Hiroaki Adachi, Kazufumi Takano, Satoshi Murakami, Tsuyoshi Inoue, Yusuke Mori, Hiroyoshi Matsumura & Bunzo Mikami
   Acta Cryst. (2015) F71, 132-135.

(188)
Selective Crystallization of the Metastable Phase of Indomethacin on the Interface of Liquid/air Bubble Induced by the Femtosecond Laser Irradiation
   Kenji Ikeda, Mihoko Maruyama, Yoshinori Takahashi, Yoichiro Mori, Hiroshi Y. Yoshikawa, Shino Okada, Hiroaki Adach, Shigeru Sugiyama, Kazufumi Takano, Satoshi Murakami, Hiroyoshi Matsumura, Tsuyoshi Inoue, Masashi Yoshimura & Yusuke Mori
   Appl. Phys. Express (2015) 8, 045501.

(189)
Spiral Growth can Enhance both the Normal Growth Rate and Quality of Tetragonal Lysozyme Crystals Grown under a Forced Solution Flow
   Yuki Hayashi, Mihoko Maruyama, Masashi Yoshimura, Shino Okada, Hiroshi Y. Yoshikawa, Shigeru Sugiyama, Hiroaki Adachi, Hiroyoshi Matsumura, Tsuyoshi Inoue, Kazufumi Takano, Satoshi Murakami & Yusuke Mori
   Cryst. Growth Des. (2015) 15, 2137-2143.

(190)
Selective Crystallization of Metastable Phase of Acetaminophen by Ultrasonic Irradiation
   Yoichiro Mori, Mihoko Maruyama, Yoshinori Takahashi, Kenji Ikeda, Suguru Fukukita, Hiroshi Y. Yoshikawa, Shino Okada, Hiroaki Adach, Shigeru Sugiyama, Kazufumi Takano, Satoshi Murakami, Hiroyoshi Matsumura, Tsuyoshi Inoue, Masashi Yoshimura & Yusuke Mori
   Appl. Phys. Express (2015) 8, 065501.

(191)
Development of Protein Seed Crystals Reinforced by High-strength Hydrogels
   Shigeru Sugiyama, Noriko Shimizu, Keisuke Kakinouchi, Osamu Hiraoka, Hiroyoshi Matsumura, Hiroshi Y. Yoshikawa, Yoshinori Takahashi, Mihoko Maruyama, Masashi Yoshimura, Hiroaki Adachi, Kazufumi Takano, Satoshi Murakami, Tsuyoshi Inoue, Michio Murata & Yusuke Mori
   CrystEngComm (2015) 17, 8064-8071.

(192)
Effects of Surfactant and a Hyperthermostable Protease on Infectivity of Scrapie-Infected Mouse Brain Homogenate
   Azumi Hirata, Akikazu Sakudo, Kazufumi Takano, Shigenori Kanaya & Yuichi Koga
   J. Biotechnol. Biomater. (2015) 5, 194.

(193)
Slow Unfolding Pathway of the Hyperthermophilic Tk-RNase H2 Examined by Pulse Proteolysis Using Mutant Proteins
   Kanako Shima, Ai Nagao, Jun Okada, Satoshi Sano & Kazufumi Takano
   Biochem. Anal. Biochem. (2015) 4, 213.

2016

(194)
A Crystallization Technique for Obtaining Large Protein Crystals with Increased Mechanical Stability Using Agarose Gel Combined with a Stirring Technique
   Mihoko Maruyama, Yuki Hayashi, Hiroshi Y. Yoshikawa, Shino Okada, Haruhiko Koizumi, Masaru Tachibana, Shigeru Sugiyama, Hiroaki Adachi, Hiroyoshi Matsumura, Tsuyoshi Inoue, Kazufumi Takano, Satoshi Murakami, Masashi Yoshimura & Yusuke Mori
   J. Cryst. Growth (2016) 452, 172-178.

(195)
Growth of High-strength Protein Crystals with Nanofibers
   Miki Matsuoka, Keisuke Kakinouchi, Hiroaki Adachi, Mihoko Maruyama, Shigeru Sugiyama, Iori Nakabayashi, Hiroshi Tsuchikura, Atsushi Kuwahara, Satoshi Sano, Hiroshi Y. Yoshikawa, Yoshinori Takahashi, Masashi Yoshimura, Hiroyoshi Matsumura, Satoshi Murakami, Tsuyoshi Inoue, Yusuke Mori & Kazufumi Takano
   Appl. Phys. Express (2016) 9, 035503.

(196)
Protein Crystallization with Paper
   Miki Matsuoka, Keisuke Kakinouchi, Hiroaki Adachi, Mihoko Maruyama, Shigeru Sugiyama, Satoshi Sano, Hiroshi Y. Yoshikawa, Yoshinori Takahashi, Masashi Yoshimura, Hiroyoshi Matsumura, Satoshi Murakami, Tsuyoshi Inoue, Yusuke Mori & Kazufumi Takano
   Jpn. J. Appl. Phys. (2016)
55, 050302.

(197)
Molecular Mechanism Underlying Promiscuous Polyamine Recognition by Spermidine Acetyltransferase
   Shigeru Sugiyama, Sae Ishikawa, Hideyuki Tomitori, Mayumi Niiyama, Mika Hirose, Yuma Miyazaki, Kyohei Higashi, Michio Murata, Hiroaki Adachi, Kazufumi Takano, Satoshi Murakami, Tsuyoshi Inoue, Yusuke Mori, Keiko Kashiwagi, Kazuei Igarashi & Hiroyoshi Matsumura
   Int. J. Biochem. Cell Biol. (2016) 76, 87-97.

(198)
Behavior of Bovine Serum Albumin Molecules in Molecular Crowding Environments Investigated by Raman Spectroscopy
   Chikashi Ota & Kazufumi Takano
   Langmuir (2016)
32, 7372-7382.

(B12) Hyperthermophilic Subtilisin-like Proteases from Thermococcus kodakarensis
   Ryo Uehara, Kazufumi Takano, Shigenori Kanaya & Yuichi Koga
   Biotechnology of Microbial Enzymes (G. Brahmachari, ed.) (2016) pp. 81-117, Elsevier, Amsterdam (Netherlands).

(R37)
何でもアリ?のタンパク質の結晶化方法
   高野和文
   生物工学会誌 (2016) 94, 704-707.

(199)
Promotion of Protein Crystal Growth by Actively Switching Crystal Growth Mode via Femtosecond Laser Ablation
   Yusuke Tominaga, Mihoko Maruyama, Masashi Yoshimura, Haruhiko Koizumi, Masaru Tachibana, Shigeru Sugiyama, Hiroaki Adachi, Katsuo Tsukamoto, Hiroyoshi Matsumura, Kazufumi Takano, Satoshi Murakami, Tsuyoshi Inoue, Hiroshi Y. Yoshikawa & Yusuke Mori
   Nat. Photonics (2016) 10, 723-726.

(200)
Folding and Unfolding Kinetics of Unpurified Proteins by Pulse Proteolysis
   Kanako Shima, Jun Okada, Satoshi Sano & Kazufumi Takano
   Protein Pept. Lett. (2016) 23, 976-987.

2017


(201)
Metastable Crystal Growth of Acetaminophen Using Solution-mediated Phase Transformation
   Yoichiro Mori, Mihoko Maruyama, Yoshinori Takahashi, Hiroshi Y. Yoshikawa, Shino Okada, Hiroaki Adach, Shigeru Sugiyama, Kazufumi Takano, Satoshi Murakami, Hiroyoshi Matsumura, Tsuyoshi Inoue, Masashi Yoshimura & Yusuke Mori
   Appl. Phys. Express (2017) 10, 015501.

(B13)
レーザーによるタンパク質結晶の作製と加工
   高野和文
   科学立国 日本を築くPartII 次代を拓く気鋭の研究者たち、日刊工業新聞社 (2017) 195-201.

(202)
Crystallization of Acetaminophen Form II by Plastic-ball-assisted Ultrasonic Irradiation
   Yoichiro Mori, Mihoko Maruyama, Yoshinori Takahashi, Hiroshi Y. Yoshikawa, Shino Okada, Hiroaki Adach, Shigeru Sugiyama, Kazufumi Takano, Satoshi Murakami, Hiroyoshi Matsumura, Tsuyoshi Inoue, Masashi Yoshimura & Yusuke Mori
   Appl. Phys. Express (2017) 10, 025501.

(203)
Alkyne Tagged Raman Probes for Protein by Chemical Modification Approach
   Chikashi Ota, Takahiro Furukawa, Kanako Shima, Satoshi Sano, Kouji Kuramochi, Kazunori Tsubaki, Shintaro Noguchi & Kazufumi Takano
   ChemistrySelect (2017) 2, 1267-1270.

(204)
Structural Basis for the Serratia marcescens Lipase Secretion System: Crystal Structures of the Membrane Fusion Protein and Nucleotide-binding Domain
   Daichi Murata, Hiroyuki Okano, Clement Angkawidjaja, Masato Akutsu, Shun-ichi Tanaka, Kenyu Kitahara, Takuya Yoshizawa, Hiroyoshi Matsumura, Yuji Kado, Eiichi Mizohata, Tsuyoshi Inoue, Satoshi Sano, Yuichi Koga, Shigenori Kanaya & Kazufumi Takano
   Biochemistry (2017) 56, 6281-6291.

2018


(205)
Improvement of Metastable Crystal of Acetaminophen by Control of Crystal Growth Rate
   Kosuke Nii, Mihoko Maruyama, Shino Okada, Hiroaki Adach, Kazufumi Takano, Satoshi Murakami, Hiroshi Y. Yoshikawa, Hiroyoshi Matsumura, Tsuyoshi Inoue, Masayuki Imanishi, Katsuo Tsukamoto, Masashi Yoshimura & Yusuke Mori
   Appl. Phys. Express (2018) 11, 035501.

(206)
Protein Evolution is Potentially Governed by Protein Stability; Directed Evolution of an Esterase from the Hyperthermophilic Archaeon Sulfolobus tokodaii
   Ryo Kurahashi, Satoshi Sano & Kazufumi Takano
   J. Mol. Evol. (2018) 86, 283-292.

(207)
The Direction of Protein Evolution is Destined by the Stability
   Natsuko Ota, Ryo Kurahashi, Satoshi Sano & Kazufumi Takano
   Biochimie (2018) 150, 100-109.

(O3)
子育て教職員のランチ会は楽しい
   高野和文
   理系女性のライフプラン−あんな生き方・こんな生き方 研究・結婚・子育てみんなどうしてる?−(丸山美帆子・長濱祐美編)、メディカル・サイエンス・インターナショナル (2003) 98-101.

(208)
Atomic-scale Imaging of Surface and Hydration Structures of Stable and Metastable Acetaminophen Crystals by Frequency Modulation Atomic Force Microscopy
   Naritaka Kobayashi, Mihoko Maruyama, Yoichiro Mori, Suguru Fukukita, Hiroaki Adach, Kazufumi Takano, Satoshi Murakami, Hiroyoshi Matsumura, Tsuyoshi Inoue, Masashi Yoshimura, Seiichiro Nakabayashi, Yusuke Mori & Hiroshi Y. Yoshikawa
   J. Phys. Chem. C (2018) 122, 2198321990.

(209)
Growth of High-quality Metastable Crystal of Acetaminophen using Solution-mediated Phase Transformation at Low Supersaturation
   Riki Fujimoto, Mihoko Maruyama, Yoichiro Mori, Shino Okada, Hiroaki Adach, Hiroshi Y. Yoshikawa, Kazufumi Takano, Satoshi Murakami, Hiroyoshi Matsumura, Tsuyoshi Inoue, Masayuki Imanishi, Katsuo Tsukamoto, Masashi Yoshimura & Yusuke Mori
   J. Cryst. Growth (2018) 502, 76-82.

(210)
Expression and Characterization of Functional Domains of FK506-binding Protein 35 from Plasmodium knowlesi
   Carlmond Kah Wun Goh, Jovi Silvester, Wan Nur Shuhaida Wan Mahadi, Lee Ping Chin, Lau Tiek Ying, Thean Chor Leow, Ryo Kurahashi, Kazufumi Takano & Cahyo Budiman
   Protein Eng. Des. Sel. (2018) 31, 489-498.


2019

(211)
Anaerobic Glycerol-3-phosphate Dehydrogenase Complex from Hyperthermophilic Archaeon Thermococcus kodakarensis KOD1
   Yuichi Koga, Kanako Konishi, Atsushi Kobayashi, Shigenori Kanaya & Kazufumi Takano
   J. Biosci. Bioeng. (2019) 127, 679-685.

(212)
Crystallization of Aspirin Form II by Femtosecond Laser Irradiation
   Yuka Tsuri, Mihoko Maruyama, Riki Fujimoto, Shino Okada, Hiroaki Adachi, Hiroshi Y. Yoshikawa, Kazufumi Takano, Satoshi Murakami, Hiroyoshi Matsumura, Tsuyoshi Inoue, Katsuo Tsukamoto, Masayuki Imanishi, Masashi Yoshimura & Yusuke Mori
   Appl. Phys. Express (2019) 12, 015507.

(B14) Development of Polymorphic Control Technology for Pharmaceutical Compounds
   Mihoko Maruyama, Masashi Yoshimura, Kazufumi Takano & Yusuke Mori
   Kinetic Control in Synthesis and Self-assembly (M. Numata, S. Yagai & T. Hamura, eds.) (2019) pp. 269-291, Elsevier, Amsterdam (Netherlands).

(213)
Large-scale Crystallization of Acetaminophen Trihydrate by a Novel Stirring Technique
   Riki Fujimoto, Mihoko Maruyama, Shino Okada, Hiroaki Adach, Hiroshi Y. Yoshikawa, Kazufumi Takano, Masayuki Imanishi, Katsuo Tsukamoto, Masashi Yoshimura & Yusuke Mori
   Appl. Phys. Express (2019) 12, 045503.

(214)
Activity-stability Trade-off in Random Mutant Proteins
   Ryo Kurahashi, Shun-ichi Tanaka & Kazufumi Takano
   J. Biosci. Bioeng. (2019) 128, 405-409.

(215)
Spectroscopic Analysis of Protein Crowded Environments Using the Charge-transfer Fluorescence Probe 8-anilino-1-naphthalenesulfonic Acid
   Chikashi Ota & Kazufumi Takano
   ChemPhysChem (2019) 20, 1456-1466.

(R38)
タンパク質の分子進化における構造安定性の役割
   高野和文
   生物物理 (2019) 59, 314-316.

2020

(B14)
蛋白質の安定性と分子進化
   高野和文
   熱量測定・熱分析ハンドブック 第3版、日本熱測定学会・丸善 (2020) 271.

(216)
Affinity Shift of ATP upon Glycerol Binding to a Glycerol Kinase from the Hyperthermophilic Archaeon Thermococcus kodakarensis KOD1
   Ryuta Hokao, Hiroyoshi Matsumura, Ryota Katsumi, Clement Angkawidjaja, Kazufumi Takano, Shigenori Kanaya & Yuichi Koga
   J. Biosci. Bioeng. (2020) 129, 657-663.

(217)
Spectroscopic Signature of the Steric Strains in an Escherichia coli RNase HI Cavity-filling Destabilized Mutant Protein
   Chikashi Ota, Hikari Suzuki, Shun-ichi Tanaka & Kazufumi Takano
   J. Phys. Chem. B (2020) 124, 91-100.

(218)
Intergrowth of Two Aspirin Polymorphism Observed with Raman Spectroscopy
   Yuka Tsuri, Mihoko Maruyama, Hiroshi Y. Yoshikawa, Shino Okada, Hiroaki Adachi, Kazufumi Takano, Katsuo Tsukamoto, Masayuki Imanishi, Masashi Yoshimura & Yusuke Mori
   J. Cryst. Growth (2020) 532, 125430.

(219)
Stress Responses of Shade-treated Tea Leaves to High Light Exposure after Removal of Shading
   Satoshi Sano, Tetsuyuki Takemoto, Akira Ogihara, Kengo Suzuki, Takehiro Masumura, Shigeru Satoh, Kazufumi Takano, Yutaka Mimura & Shigeto Morita
   Plants (2020) 9, 302.

(B15)
医薬品化合物の結晶化技術
   丸山美帆子、吉村政志、高野和文、森勇介
   医薬品原薬の結晶化と物性評価:その最先端技術と評価の実際、シーエムシー出版、(2020) 3-20.

(220)
Microflow System Promotes Acetaminophen Crystal Nucleation
   Akari Nishigaki, Mihoko Maruyama, Munenori Numata, Chisako Kanzaki, Shun-ichi Tanaka, Hiroshi Y. Yoshikawa, Masayuki Imanishi, Masashi Yoshimura, Yusuke Mori & Kazufumi Takano
   Eng. Life Sci. (2020) 20, 395-401.

(221)
Highly Active Enzymes Produced by Directed Evolution with Stability-based Selection
   Ryo Kurahashi, Shun-ichi Tanaka & Kazufumi Takano
   Enzyme Microb. Technol. (2020) 140, 109626.

(222)
Crystal Structure of a GH1 β-Glucosidase from Hamamotoa singularis
   Ryo Uehara, Riki Iwamoto, Sayaka Aoki, Takuya Yoshizawa, Kazufumi Takano, Hiroyoshi Matsumura & Shun-ichi Tanaka
   Protein Sci. (2020) 29, 2000-2008.

(223)
Spectroscopic Evidence of the Salt-induced Conformational Change around the Localized Electric Charges on the Protein Surface of Fibronectin Type III
   Chikashi Ota, Yui Fukuda, Shun-ichi Tanaka & Kazufumi Takano
   Langmuir (2020) 36, 14243-14254.

2021

(224)
Insertion Loop-mediated Folding Propagation Governs Efficient Maturation of Hyperthermophilic Tk-subtilisin at High Temperatures
   Ryo Uehara, Nanako Dan, Hiroshi Amesaka, Takuya Yoshizawa, Yuichi Koga, Shigenori Kanaya, Kazufumi Takano, Hiroyoshi Matsumura & Shun-ichi Tanaka
   FEBS Lett. (2021) 595, 452-461.

(225)
Effects of Entrapped Gas on the Surface of a Plastic Ball Induced by Ultrasonic Irradiation on the Enhancement of Crystallization of Acetaminophen Form II
   Yuka Tsuri, Nana Inaoka, Mihoko Maruyama, Hiroaki Adachi, Hiroshi Y. Yoshikawa, Kazufumi Takano, Katsuo Tsukamoto, Masayuki Imanishi, Masashi Yoshimura & Yusuke Mori
   J. Cryst. Growth (2021) 557, 125994.

(226)
Exploring Mutable Conserved Sites and Fatal Non-conserved Sites by Random Mutation of Esterase from Sulfolobus tokodaii and Subtilisin from Thermococcus kodakarensis
   Shun-ichi Tanaka, Minami Tsutaki, Seira Yamamoto, Hayate Mizutani, Ryo Kurahashi, Azumi Hirata & Kazufumi Takano
   Int. J. Biol. Macromol. (2021) 170, 343-353.

(227)
Revisiting the Rate Limiting Step of the ANS-Protein Binding at the Protein Surface and Inside the Hydrophobic Cavity
   Chikashi Ota, Shun-ichi Tanaka & Kazufumi Takano
   Molecules (2021) 26, 420.

(228)
Multicolor Imaging of Calcium-binding Proteins in Human Kidney Stones for Elucidating the Effects of Proteins on Crystal Growth
   Yutaro Tanaka, Mihoko Maruyama, Atsushi Okada, Yoshihiro Furukawa, Koichi Momma, Yuki Sugiura, Rie Tajiri, Koichi Sawada, Shun-ichi Tanaka, Kazufumi Takano, Kazumi Taguchi, Shuzo Hamamoto, Ryosuke Ando, Katsuo Tsukamoto, Masashi Yoshimura, Yusuke Mori & Takahiro Yasui
   Sci. Rep. (2021) 11, 16841.

(229)
Growth of Acetaminophen Polymorphic Crystals and Solution-mediated Phase Transition from Trihydrate to Form II in Agarose Gel
   Akari Nishigaki, Mihoko Maruyama, Shun-ichi Tanaka, Hiroshi Y. Yoshikawa, Masayuki Imanishi, Masashi Yoshimura, Yusuke Mori & Kazufumi Takano
   Crystals (2021) 11, 1069.

2022

(MP2)
断熱型示差走査熱量計(DSC)を用いた蛋白質の熱安定性解析(改訂)
   向山厚、高野和文
   蛋白質科学会アーカイブ (2008) 1, e039.

(O4)
今、ハンナ・アーレント(1906-1975)に出会って
   高野和文
   京都府立大学図書館報「なからぎ」 (2022) 238, 2-3.

(230)
Effects of Pulse Duration on Laser-induced Crystallization of Urea from 300 fs to 1200 fs: Impact of Cavitation Bubbles on Crystal Nucleation
   Yuka Tsuri, Mihoko Maruyama, Katsuo Tsukamoto, Hiroaki Adachi, Kazufumi Takano, Shigeyoshi Usami, Masayuki Imanishi, Masashi Yoshimura, Hiroshi Y. Yoshikawa & Yusuke Mori
   Appl. Phys. A (2022) 128, 803.

(231)
Metastable Crystallization by Drop Impact
   Akari Nishigaki, Mihoko Maruyama, Shun-ichi Tanaka, Hiroshi Y. Yoshikawa, Masayuki Imanishi, Masashi Yoshimura, Yusuke Mori & Kazufumi Takano
   Crystals (2022) 12, 1104.

(232)
Heterologous Expression and Catalytic Properties of Codon-Optimized Small-Sized Bromelain from MD2 Pineapple
   Rafida Razali, Fikran Ananda Fakhrudin, Vijay Kumar Subbiah, Kazufumi Takano & Cahyo Budiman
   Molecules (2022) 27, 6031.

(233)
Dispersion Effect of Molecular Crowding on Ligand-Protein Surface Binding Sites of Escherichia coli RNase HI
   Chikashi Ota, Hikari Suzuki, Shun-ichi Tanaka & Kazufumi Takano
   Langmuir (2022) 38, 1449714507.

2023

(B16) Hyperthermophilic Subtilisin-like Proteases from Thermococcus kodakarensis
   Ryo Uehara, Hiroshi Amesaka, Yuichi Koga, Kazufumi Takano, Shigenori Kanaya & Shun-ichi Tanaka
   Biotechnology of Microbial Enzymes 2nd edition (G. Brahmachari, ed.) (2023) pp. 89-127, Elsevier, Amsterdam (Netherlands).

(234)
Real-time Monitoring of Polyacrylamide Gel Electrophoresis by the Shadowgraph Technique
   Satoshi Murakami, Hiroaki Adachi, Hiroyoshi Matsumura, Kazufumi Takano, Tsuyoshi Inoue & Yusuke Mori
   J. Biochem. (2023) 173, 65-72.

(235)
Solution-mediated Phase Transition of Pharmaceutical Compounds: Case Studies of Acetaminophen and Aspirin
   Mihoko Maruyama, Hiroshi Y. Yoshikawa, Kazufumi Takano, Masashi Yoshimura & Yusuke Mori
   J. Cryst. Growth (2023) 602, 126990.

(236)
Quantitative Analysis of Calcium Oxalate Monohydrate and Dihydrate for Elucidating the Formation Mechanism of Calcium Oxalate Kidney Stones
   Mihoko Maruyama, Koichi P. Sawada, Yutaro Tanaka, Atsushi Okada, Koichi Momma, Masanori Nakamura, Ryota Mori, Yoshihiro Furukawa, Yuki Sugiura, Rie Tajiri, Kazumi Taguchi, Shuzo Hamamoto, Ryosuke Ando, Katsuo Tsukamoto, Kazufumi Takano, Masayuki Imanishi, Masashi Yoshimura, Takahiro Yasui & Yusuke Mori
   PLOS ONE (2023) 18, e0282743.

(237)
Evidence for Solution-mediated Phase Transitions in Kidney Stones -Phase Transition Exacerbates Kidney Stone Disease-
   Mihoko Maruyama, Yutaro Tanaka, Koichi Momma, Yoshihiro Furukawa, Hiroshi Y. Yoshikawa, Rie Tajiri, Masanori Nakamura, Kazumi Taguchi, Shuzo Hamamoto, Ryosuke Ando, Katsuo Tsukamoto, Kazufumi Takano, Masayuki Imanishi, Shigeyoshi Usami, Kenjiro Kohri, Atsushi Okada, Takahiro Yasui, Masashi Yoshimura & Yusuke Mori
   Cryst. Growth Des. (2023) 23, 4285-4293.

(238)
Structure, Stability and Binding Properties of Collagen-binding Domains from Streptococcus mutans
   Akari Nishi, Hikaru Matsui, Azumi Hirata, Atsushi Mukaiyama, Shun-ichi Tanaka, Takuya Yoshizawa, Hiroyoshi Matsumura, Ryota Nomura, Kazuhiko Nakano & Kazufumi Takano
   Chemistry (2023) 5, 1911-1920.

(O5) The
京都、The京都府立大学
   高野和文
   大阪大学工学部生物工学系同窓会 尚醸会会報 (2023) 26, 13.

2024

(239)
Induced Circular Dichroism Analysis of Thermally Induced Conformational Changes on Protein Binding Sites Under a Crowding Environment
   Chikashi Ota, Tomoya Konishi, Shun-ichi Tanaka & Kazufumi Takano
   ChemPhysChem (2024) 25, e202300593.

(240)
Calcium Phosphate Controls Nucleation and Growth of Calcium Oxalate Crystal Phases in Kidney Stones
   Uta Michibata, Mihoko Maruyama, Yutaro Tanaka, Masashi Yoshimura, Hiroshi Y. Yoshikawa, Kazufumi Takano, Yoshihiro Furukawa, Koichi Momma, Rie Tajiri, Kazumi Taguchi, Shuzo Hamamoto, Atsushi Okada, Kenjiro Kohri, Takahiro Yasui, Shigeyoshi Usami, Masayuki Imanishi & Yusuke Mori
   Biomed. Res. (Tokyo) (2024) 45, 103-113.

(241)
The Impact of Crystal Phase Transition on the Hardness and Structure of Kidney Stones
   Uta Michibata, Mihoko Maruyama, Yutaro Tanaka, Masashi Yoshimura, Hiroshi Y. Yoshikawa, Kazufumi Takano, Yoshihiro Furukawa, Koichi Momma, Rie Tajiri, Kazumi Taguchi, Shuzo Hamamoto, Atsushi Okada, Kenjiro Kohri, Takahiro Yasui, Shigeyoshi Usami, Masayuki Imanishi & Yusuke Mori
   Urolithiasis (2024) 52, 57.

(242)
Role of N1-domain, Linker, N2-domain, and Latch in the Binding Activity and Stability of the Collagen-binding Domain for the Collagen-binding Protein Cbm from Streptococcus mutans
   Akari Nishi, Azumi Hirata, Atsushi Mukaiyama, Shun-ichi Tanaka, Ryota Nomura, Kazuhiko Nakano & Kazufumi Takano
   Physchem (2024) 4, 120-130.

(243)
Utilization of Low-stability Variants in Protein Evolutionary Engineering
   Mitsutoshi Wakisaka, Shun-ichi Tanaka & Kazufumi Takano
   Int. J. Biol. Macromol. (2024) 272, 132946.






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