研究活動


メンバー:

教授: 岩﨑 有作

特任助教: 1名

博士後期課程1年: 1名

博士前期課程2年: 3名

博士前期課程1年: 3名

学部4年: 4名


研究紹介(研究業績):

原著論文

* Equally contributed, Corresponding author

1      Ohbayashi, K., Oyama, Y., Yamaguchi, C., Asano, T., Yada, T. and Iwasaki, Y.: Gastrointestinal distension by pectin-containing carbonated solution suppresses food intake and enhances glucose tolerance via GLP-1 secretion and vagal afferent activation. Front. Endocrinol., 12:6768695 (2021)

2      Wang, L., Han, W., Iwasaki, Y., Yermek, R., Sharp, G.W.G., Seino, Y., Yada, T.: Onion component, isoalliin, stimulates feeding and activates the arcuate nucleus neuropeptide Y, ghrelin- and Ninjin'yoeito-responsive neurons. Neuropeptide, 89:102180 (2021)

3      Teratani, T., Mikami, Y., Nakamoto, N., Suzuki, T., Harada, Y., Okabayashi, K., Hagihara, Y., Taniki, N., Kohno, K., Sibata, S., Miyamoto, K., Ishigame, H., Chu, P.S., Sujino, T., Suda, W., Hattori, M., Matsui, M., Okada, T., Okano, H., Inoue, M., Yada, T., Kitagawa, Y., Yoshimura, A., Tanida, M., Tsuda, M., Iwasaki, Y. and Kanai, T.: The Liver-Brain-Gut Neural Arc Maintains the T reg Cell Niche in the Gut. Nature, 484(7826): 591-596 (2020)

4      Yoshino, S., Iwasaki, Y., Matsumoto, S., Satoh, T., Ozawa, A., Yamada, E., Kakizaki, S., Trejo, JAO., Uchiyama, Y., Yamada, M. and Mori, M.: Administration of small-molecule guanabenz acetate attenuates fatty liver and hyperglycemia associated with obesity. Sci. Rep., 10(1):13671 (2020)

5      Yamamuro, D., Takahashi, M., Nagashima, S., Wakabayashi, T., Yamazaki, H., Takei, A., Takei, S., Sakai, K., Ebihara, K., Iwasaki, Y., Yada, T., and Ishibashi, S.: Peripheral Circadian Rhythms in the Liver and White Adipose Tissue of Mice Are Attenuated by Constant Light and Restored by Time-Restricted Feeding. PLoS One, 15(6):e0234439 (2020)

6      Iwasaki, Y.,*† Kumari, P.,* Wang, L., Hidema, S., Nishimori, K. and Yada, T.†: Relay of peripheral oxytocin to central oxytocin neurons via vagal afferents for regulating feeding.Biochem. Biophys. Res. Commun., 519:553-558 (2019)

7      Tanida, M., Iwasaki, Y. and Yamamoto, N.: Central injection of leptin increases sympathetic nerve outflows to the stomach and spleen in anesthetized rats. In Vivo, 33:1827-1832 (2019)

8      Hashidume, T., Sasaki, K., Hirata, J., Kato, M., Yoshikawa, Y., Iwasaki, Y., Arai, H., Miura, S. and Miyoshi, N.: Effects of sanyaku and its constituent diosgenin on the fasted and postprandial hypertriacylglycerolemia in high-fat-diet-fed KK-Ay mice. J. Agric. Food Chem. 66(38):9968-9975 (2018)

9      Goswami, C., Iwasaki, Y. and Yada, T. : Short chain fatty acids suppress food intake by activating vagal afferent neurons. J. Nutr. Biochem., 57:130-135 (2018)

10    Iwasaki, Y., Sendo, M., Dezaki, K., Hira, T., Sato, T., Nakata, M., Goswami, G., Aoki, R., Arai, T., Kumari, P., Hayakawa, M., Masuda, C., Okada, T., Hara, H., Drucker, D.J., Yamada, Y., Tokuda, M. and Yada, T.: GLP-1 release and vagal afferent activation mediate the beneficial metabolic and chronotherapeutic effects of D-allulose. Nat. Commun. 9:113 (2018)

11    Yoshii, Y., Inoue, T., Uemura1, Y., Iwasaki, Y., Yada, T., Nakabeppu, Y. and Noda, M.: Complexity of stomach–brain interaction induced by molecular hydrogen in Parkinson’s disease model mice. Neurochem. Res. 42:2658-2665 (2017)

12    Iwasaki, Y., Goswami, C., and Yada, T.: Glucagon-like peptide-1 and insulin synergistically activate vagal afferent neurons. Neuropeptide, 65:77-82 (2017)

13    Oi-Kano, Y., Iwasaki, Y., Nakamura, T., Watanabe, T., Goto, T., Kawada, T., Watanabe, K., and Iwai, K.: Oleuropein aglycone enhances UCP1 expression in brown adipose tissue in high-fat-diet-induced obese rats by activating β-adrenergic signaling. J. Nutr. Biochem., 40:209-218 (2016)

14    Kimura, H., Karasawa, T., Usui, F., Kawashima, A., Endo, Y., Kobayashi, M., Sadatomo, A., Nakamura, J., Iwasaki, Y., Yada, T., Tsutsui, H., Kasahara, T., and Takahashi, M.: Caspase-1 deficiency promotes high-fat diet-induced adipose tissue inflammation and the development of obesity. Am. J. Physiol. Endocrinol. Metab., 11(5):E881-890 (2016)

15    Kimura, H., Usui, F., Karasawa, T., Kawashima, A,. Shirasuna, K., Inoue, Y., Komada, T., Kobayashi, M., Mizushina, Y., Kasahara, T., Suzuki, K., Iwasaki, Y., Yada, T., Caturegli, P., and Takahashi, M.: Immunoproteasome subunit LMP7 deficiency improves obesity and metabolic disorders. Sci. Rep., 5:15883 (2015)

16    Sasaki, T., Kinoshita, Y., Matsui, S., Kakuta, S., Yokota-Hashimoto, H., Kinoshita, K., Iwasaki, Y., Kinoshita, T., Yada, T., Amano, N., and Kitamura, T.: N-methyl D-aspartate receptor co-agonist D-serine suppresses intake of high-preference food. Am. J. Physiol. Regul. Integr. Comp. Physiol., 309(5):R561-575 (2015)

17    Iwasaki, Y., Dezaki, K., Kumari, P., Kakei, M., and Yada, T.: Ghrelin counteracts insulin-induced activation of vagal afferent neurons via growth hormone secretagogue receptor. Neuropeptide, 52:55-60 (2015)

18    Iwasaki, Y., Majima, Y., Suyama, S., Yoshida, M., Arai, T., Katsurada, K., Kumari, P., Nakabayashi, H., Kakei, M., and Yada, T.: Peripheral oxytocin activates vagal afferent neurons to suppress feeding in normal and leptin-resistant mice: A route for ameliorating hyperphagia and obesity. Am. J. Physiol. Regul. Integr. Comp. Physiol., 308:R360-R369 (2015)

19    Ayush, E.*, Iwasaki, Y.*, Iwamoto, S., Nakabayashi, H., Kakei, M., and Yada, T.: Glucagon directly interacts with vagal afferent nodose ganglion neurons to induce Ca2+ signaling via glucagon receptors. Biochem. Biophys. Res. Commun., 456:727-732 (2015)

20    Katsurada, K., Maejima, Y., Nakata, M., Kodaira, M., Suyama, S., Iwasaki, Y., Kario, K., and Yada, T.: Endogenous GLP-1 acts on paraventricular nucleus to suppress feeding: Projection from nucleus tractus solitarius and activation of corticotropin-releasing hormone, nesfatin-1 and oxytocin neurons. Biochem. Biophys. Res. Commun., 451(2):276-281 (2014)

21    Ishizuka, Y., Nakayama, K., Ogawa, A., Makishima, S., Boonvisut, S., Hirao, A., Iwasaki, Y., Yada, T., Yanagisawa, Y., Miyashita, H., Takahashi, M., and Iwamoto, S.: TRIB1 down-regulates hepatic lipogenesis and glycogenesis via multiple molecular interactions. J. Mol. Endocrinol., 52(2):145-58 (2014)

22    Iwasaki, Y., Shimomura, K., Kohno, D., Dezaki, K., Ayush, EA., Nakabayashi, H., Kubota, N., Kadowaki, T., Kakei, M., Nakata, M., and Yada, T.: Insulin activates vagal afferent neurons including those innervating pancreas via insulin cascade and Ca2+ influx: Its dysfunction in IRS2-KO mice with hyperphagic obesity. PLoS One, 8(6):e67198 (2013), DOI: 10.1371/journal.pone.0067198

23    Yang, Y., Shimomura, K., Sakuma, K., Maejima, Y., Iwasaki, Y., Galvanovskis, J., Dezaki, K., Nakata, M., and Yada, T.: Bupropion can close KATP channel and induce insulin secretion. J. Pediatr. Endocrinol. Metab., 26(3-4):343-346 (2013)

24    Iwasaki, Y., Kakei, M., Nakabayashi, H., Ayush, EA., Hirano-Kodaira, M., Maejima, Y., and Yada, T.: Pancreatic polypeptide and peptide YY3-36 induce Ca2+ signaling in nodose ganglion neurons. Neuropeptides, 47:19-23 (2013), DOI: 10.1016/j.npep.2012.07.006.

25    Tamura, Y., Iwasaki, Y., Narukawa, M., and Watanabe, T.: Ingestion of cinnamaldehyde, a TRPA1 agonist, reduces visceral fats in high-fat and high-sucrose diet fed mice. J. Nutr. Sci. Vitaminol., 58(1):9-13 (2012)

26    Maejima, Y., Iwasaki, Y., Yamahara, Y., Kodaira, M., Sedbazar, U., and Yada, T.: Peripheral oxytocin treatment ameliorates obesity by reducing food intake and visceral fat mass. Aging, 3(12):1169-1177 (2011)

27    Maejima, Y., Kohno, D., Iwasaki, Y., and Yada T.: Insulin suppresses ghrelin-induced calcium signaling in neuropeptide Y neurons of the hypothalamic arcuate nucleus. Aging, 3(11):1092-1097 (2011)

28    Iwasaki, Y., Tamura, Y., Inayoshi, K., Narukawa, M., Kobata, K., Chiba, H., Muraki, E., Tsunoda, N., and Watanabe, T.: TRPV1 agonist monoacylglycerol increases UCP1 content in brown adipose tissue and suppresses accumulation of visceral fat in mice fed high-fat and high-sucrose diet. Biosci. Biotechnol. Biochem., 75(5):904-909 (2011)

29    Yoshida, N., Maejima, Y., Sedbazar, U., Ando, A., Kurita, H., Damdindorj, B., Takano, E., Gantulga, D., Iwasaki, Y., Kurashina, T., Onaka, T., Dezaki, K., Nakata, M., Mori, M., and Yada, T.: Stressor-responsive central nesfatin-1 activates corticotropin-releasing hormone, noradrenaline and serotonin neurons and evokes hypothalamic-pituitary-adrenal axis. Aging, 2(11):775-784 (2010)

30    Narukawa, M., Koizumi, K., Iwasaki, Y., Kubota, K., and Watanabe, T.: Galangal pungent component, 1'-Acetoxychavicol acetate, activates TRPA1. Biosci. Biotechnol. Biochem., 74(8):1694-1696 (2010)

31    Okumura, Y., Narukawa, M., Iwasaki, Y., Ishikawa, A., Matsuda, H., Yoshikawa, M., and Watanabe, T.: Activation of TRPV1 and TRPA1 by black pepper components. Biosci. Biotechnol. Biochem., 74(5):1068-1072 (2010)

32    Sasahara, I., Furuhata, Y., Iwasaki, Y., Inoue, Y., Sato, H., Watanabe, T., and Takahashi, M.: Assessment of biological similarity of three capsaicin analogs (capsinoids) found in non-pungent chili pepper (CH-19 Sweet) fruits. Biosci. Biotechnol. Biochem., 74(2):274-278 (2010)  (2010年論文賞受賞)

33    Iwasaki, Y., Nakabayashi, H., Kakei, M., Shimizu, H., Mori, M., and Yada, T.: Nesfatin-1 evokes Ca2+ signaling in isolated vagal afferent neurons via Ca2+ influx through N-type channels. Biochem. Biophys. Res. Commun., 390:958-962 (2009)

34    Iwasaki, Y., Tanabe, M., Kayama, Y., Abe, M., Kashio, M., Koizumi, K., Okumura, Y., Morimitsu, Y., Tominaga, M., Ozawa, Y., and Watanabe, T.: Miogadial and miogatrial with a,b-unsaturated 1,4-dialdehyde moieties -novel and potent TRPA1 agonists. Life Sci., 85(1-2):60-69 (2009)

35    Koizumi, K., Iwasaki, Y., Narukawa, M., Iitsuka, Y., Fukao, T., Seki, T., Ariga, T., and Watanabe, T.: Diallyl sulfides in garlic activate both TRPA1 and TRPV1. Biochem. Biophys. Res. Commun., 382:545-548 (2009)

36    Shiba, T., Maruyama, T., Kurohane, K., Iwasaki, Y., Watanabe, T., and Imai, Y.:  TRPA1 and TRPV1 activation is a novel adjuvant effect mechanism in contact hypersensitivity. J. Neuroimmunol., 207(1-2):66-74 (2009)

37    Iwasaki, Y., Tanabe, M., Kobata, K., and Watanabe, T.: TRPA1 agonists -allyl isothiocyanate and cinnamaldehyde- induce adrenalin secretion. Biosci. Biotechnol. Biochem.,72(10):2608-2614 (2008)

38    Iwasaki, Y., Saito, O., Tanabe, M., Inayoshi, K., Kobata, K., Uno, S., Morita, A., and Watanabe, T.: Monoacylglycerols activate capsaicin receptor, TRPV1. Lipids, 43:471-483 (2008)

39    Kobata, K., Tate, H., Iwasaki, Y., Tanaka, Y., Ohtsu, K., Yazawa, S., and Watanabe, T.: Isolation of coniferyl esters from Capsicum baccatum L., and their enzymatic preparation and agonist activity for TRPV1. Phytochemistry, 69(5):1179-1184 (2008)

40    Morita, A., Iwasaki, Y., Kobata, K., Yokogoshi, H., and Watanabe, T.: Newly synthesized oleylgingerol and oleylshogaol activate TRPV1 ion channels. Biosci. Biotechnol. Biochem., 71:2304-2307 (2007)

41    Iwasaki, Y., Morita, A., Iwasawa, T., Kobata, K., Sekiwa, Y., Morimitsu, Y., Kubota, K., and Watanabe, T.: A nonpungent component of steamed ginger ­-[10]-shogaol- increases adrenaline secretion via the activation of TRPV1. Nutr. Neurosci., 9:169-178 (2006)

42    Morita, A., Iwasaki, Y., Kobata, K., Iida, T., Higashi, T., Oda, K., Suzuki, A., Narukawa, M., Sasakuma, S., Yokogoshi, H., Yazawa, S., Tominaga, M., and Watanabe, T.: Lipophilicity of capsaicinoids and capsinoids influences the multiple activation process of rat TRPV1. Life Sci., 79:2303-2310 (2006)

43    Kobata, K., Iwasawa, T., Iwasaki, Y., Morita, A., Suzuki, Y., Kikuzaki, H., Nakatani, N., and Watanabe, T.: Capsaicinol: synthesis by allylic oxidation and its effect on TRPV1-expressing cells and adrenaline secretion in rats. Biosci. Biotechnol. Biochem., 70:1904-1912 (2006)

44    Sugai, E., Morimitsu, Y., Iwasaki, Y., Morita, A., Watanabe, T., and Kubota, K.: Pungent qualities of sanshool-related compounds evaluated by a sensory test and activation of rat TRPV1. Biosci. Biotechnol. Biochem., 69:1951-1957 (2005)


英文総説

1    Uchida, K., Dezaki, K., Yoneshiro, T., Watanabe, T., Yamazaki, J., Saito, M., Yada T, Tominaga, M., Iwasaki, Y.: Involvement of thermosensitive TRP channels in energy metabolism. J. Physiol. Sci., 67(5), 549-560 (2017)

2    Iwasaki, Y. and Yada, T.: Vagal afferents sense meal-associated gastrointestinal and pancreatic hormones: mechanism and physiological role. Neuropeptides, 46(6), 291-297 (2012)


総説・書籍

1    岩﨑有作、矢田俊彦:食後ホルモンインスリン・GLP-1の求心性迷走神経を介した摂食・糖代謝調節、自律神経(日本自律神経学会)、58(1): p105-113 (2021)

2    岩﨑有作、矢田俊彦:インクレチンGLP-1の摂食抑制、抗肥満・糖尿病作用 -GLP-1GLP-1受容体作動薬の作用機序の比較、実験医学(増刊)、39(5): p83-91 (2021)

3    岩﨑有作:第7章 内臓感覚神経による摂食調節、実験医学別冊 もっとよく分かる!食と栄養のサイエンス、羊土社、p80-93 (2021)

4    岩﨑有作:第8 ご飯を主食とした和食における「糖代謝」を考える、和食文化学入門、臨川書店、p181-200 (2021)

5    岩﨑有作、矢田俊彦:末梢-中枢オキシトシン連間による過食・肥満・糖尿病改善作用、糖尿病・内分泌代謝科、51(1): p28-35 (2020)

6    岩﨑有作、森光康次郎:ジンゲロールとショウガオールの体熱産生作用、Functional Food14(2): 114-119 (2020)

7    矢田俊彦、Lei Wang岩﨑有作:摂食行動を支配する腸管ホルモン・迷走神経連関、Medical Science Digest45(12)p700-703 (2019)

8    岩﨑有作、矢田俊彦:GLP-1リリーサー:希少糖アルロースの求心性迷走神経GLP-1シグナリングを介した過食、肥満、糖尿病改善、内分泌・糖尿病・代謝内科、48(6) p426-4312019

9    矢田俊彦、岩﨑有作:希少糖アルロースによるGLP-1分泌・迷走神経活性化と摂食・代謝調節、生化学、第911号、p58-642019

10 矢田俊彦、岩﨑有作:第32回糖尿病のここがわからない!?、糖尿病と希少糖のここがわからない!?Diabetes strategyVol. 9 No. 1p23-29 (2019)

11 岩﨑有作:ゼロカロリー甘味料D-AlluloseGLP-1分泌と求心性迷走神経を介した過食・肥満・糖尿病改善作用、化学と生物Vol.57 No.7p390-392 (2019)

12 岩﨑有作:甘い希少糖アルロースはカロリーゼロで満腹感を誘導し、肥満・糖尿病を改善する、ひと・健康・未来 Vol.20p36-37 (2019)

13 岩﨑有作、矢田俊彦:GLP-1による求心性迷走神経シグナリングと肥満症改、肥満研究 243号(2018

14 岩﨑有作、矢田俊彦:食関連ホルモンの求心性迷走神経を介した情報伝達による摂食調節機構、実験医学、Vol.35 No.6pp917-925 (2017)

15 岩﨑有作:糖代謝・摂食調節における自律神経の重要性と糖尿病治療標的としての期待、Diabetes strategyVol. 7 No. 1p18-19 (2017)

16 Iwasaki, Y., Yada, T., Uneyama, H., and Kitamura, A.: A role for abdominal vagal afferent signals in the regulation of food intake and metabolism, Advances in Medicine and Biology, Volume 109, Nova Science Publishers, 2016, Chapter 8

17 岩﨑有作、桂田健一、河野大輔、矢田俊彦:消化管ホルモンと迷走神経・中枢神経による摂食・代謝・生体恒常性調節、内分泌・糖尿病・代謝内科41(1)3-8 (2015)

18 岩﨑有作、矢田俊彦:自律神経系による末梢環境感知と摂食・代謝調節メタボリックシンドロームにおける変調、月刊臨床神経科学 Clinical Neuroscience321383-1386 (2014)

19 矢田俊彦、岩﨑有作:膵臓のインスリンを脳が感知する機序、日本医事新報4677, 63-65 (2013) 、査読無

20 岩﨑有作、矢田俊彦:迷走神経による消化管情報の中枢伝達と摂食制御、G.I. Research21 (1)18-24 (2013)

21 中田正範、岩﨑有作、矢田俊彦:消化管ホルモンの新機軸:インスリン分泌抑制因子、臓器連関の伝令、DPP-4阻害薬標的の視点から、Journal of Diabetes StrategyVol.2 No.124-30 (2012)

22 前島裕子、Sedbazar Udval岩﨑有作、矢田俊彦:ホルモンと神経ペプチドによる摂食調節、 Annual Review 糖尿病・代謝・内分泌 2012、寺内康夫、伊藤裕、石橋俊編集、中外医学社、東京、2012年、pp.91-97

23 前島裕子、Sedbazar Udval岩﨑有作、高野英介、矢田俊彦:Nesfatin-1の摂食抑制神経経路およびストレス、循環、生殖における役割、日本薬理学雑誌、137162-165 (2011)

24 前島裕子、Sedbazar Udval岩﨑有作、矢田俊彦:Nesfatin-1による食欲と連関機能の制御、Medical Science Digest37(2)24-26 (2011)

25 矢田俊彦、前島裕子、Sedbazar Udval岩﨑有作、中田正範:新しい摂食抑制因子Nesfatin-1 –摂食中枢経路の解明と肥満治療へのブレークスルー、臨床栄養116(2)128-129 (2010)

26 岩﨑有作、前島裕子、前川文彦、矢田俊彦:末梢臓器による摂食調節、日本臨牀68巻増刊号2号、64-70 (2010)

27 須山成朝、高野英介、岩﨑有作、中田正範、矢田俊彦:摂食調節における消化管・脳幹・視床下部・大脳辺縁系の役割と機能連関、日本臨牀、672号、277-286 (2009)

28 Watanabe, T., Iwasaki, Y., Morita, A. and Kobata, K.: Food compounds activation capsaicin receptor TRPV1, Nutrigenomics and Proteomics in Health and Disease: Food Factors and Gene Interactions, Mine, Y., Miyashita, Kazuo. And Shahidi F. (eds.), Wiley-blackwell, 2009, pp. 263-272

29 渡辺達夫、岩﨑有作、古旗賢二、守田昭仁、第3章 TRPV1を活性化する食品成分(3. TRPV1活性評価法、4. TRPV1を活性化する食品成分の一部を担当)、食品の生理機能評価法実験系とツールの新展開を目指してー、津田孝範、堀尾文彦、横越英彦責任編集、建帛社、東京、2007年、pp. 49-67.

30 渡辺達夫、古旗賢二、守田昭仁、岩﨑有作: 無・低辛味カプサイシン同族体オルバニルについて、 FFIジャーナル(食品・食品添加物研究誌)、210(3)214-221 (2005)

31 岩﨑有作、守田昭仁、古旗賢二、菅井恵津子、森光康次郎、久保田紀久枝、渡辺達夫: トウガラシ辛味成分であるカプサイシンの受容体 (TRPV1)を活性化する食品成分、応用薬理69(1/2)18-20 (2005)


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