業績 of New Site 5

業績

Red ginseng extracts attenuate skin inflammation in atopic dermatitis through p70 ribosomal protein S6 kinase activation.

• Osada-Oka M, Sayaka Hirai, Yasukatsu Izumi, Kazuhiro Misumi, Keiichi, Samukawa, Shuhei Tomita, Katsuyuki Miura, Yukiko Minamiyama, Hiroshi Iwao.
• J Phermacol Sci. in press

S-allyl-glutathione improves experimental liver fibrosis by regulating Kupffer cell activation in rats.

• Takemura S, Azuma H, Osada-Oka M, Kubo S, Shibata T, Minamiyama Y.
• Am J Physiol Gastrointest Liver Physiol. 2017 Sep 28:ajpgi.00023.2017

Spatial distribution and risk factors of Schistosoma haematobium and hookworm infections among schoolchildren in Kwale, Kenya.

• Chadeka EA, Nagi S, Sunahara T, Cheruiyot NB, Bahati F, Ozeki Y, Inoue M, Osada-Oka M, Okabe M, Hirayama Y, Changoma M, Adachi K, Mwende F, Kikuchi M, Nakamura R, Kalenda YDJ, Kaneko S, Hirayama K, Shimada M, Ichinose Y, Njenga SM, Matsumoto S, Hamano S.
• PLoS Negl Trop Dis. 11, e0005872, 2017

Macrophage-derived exosomes induce inflammatory factors in endothelial cells under hypertensive conditions.

• Osada-Oka M, Shiota M, Izumi Y, Nishiyama M, Tanaka M, Yamaguchi T, Sakurai E, Miura K, Iwao H.
• Hypertens Res. 40, 353-360, 2017

Carbon monoxide-releasing molecule, CORM-3, modulates alveolar macrophage M1/M2 phenotype in vitro.

• Yamamoto-Oka H, Mizuguchi S, Toda M, Minamiyama Y, Takemura S, Shibata T, Cepinskas G, Nishiyama N.
• Inflammopharmacology. 2017 Jul 3. doi: 10.1007/s10787-017-0371-y.

Attenuation of Bleomycin-Induced Pulmonary Fibrosis in Rats with S-Allyl Cysteine.

• Tsukioka T, Takemura S, Minamiyama Y, Mizuguchi S, Toda M, Okada S.
• Molecules. 2017 Mar 29;22(4). pii: E543. doi: 10.3390/molecules22040543

Chasing great paths of Helmut Sies "Oxidative Stress".

• Majima HJ, Indo HP, Nakanishi I, Suenaga S, Matsumoto K, Matsui H, Minamiyama Y, Ichikawa H, Yen HC, Hawkins CL, Davies MJ, Ozawa T, St Clair DK.
• Arch Biochem Biophys. 2016 Apr 1;595:54-60. doi: 10.1016/j.

Identification of low-abundance proteins in serum via the isolation of HSP72 complexes.

• Tanaka M, Shiota M, Nakao T, Uemura R, Nishi S, Ohkawa Y, Matsumoto M, Yamaguchi M, Osada-Oka M, Inagaki A, Takahashi K, Nakayama KI, Gi M, Izumi Y, Miura K, Iwao H.
• J Proteomics. 136, 214-21, 2016

A New Screen for Tuberculosis Drug Candidates Utilizing a Luciferase-Expressing Recombinant Mycobacterium bovis Bacillus Calmette-Guéren.

• Ozeki Y, Igarashi M, Doe M, Tamaru A, Kinoshita N, Ogura Y, Iwamoto T, Sawa R, Umekita M, Enany S, Nishiuchi Y, Osada-Oka M, Hayashi T, Niki M, Tateishi Y, Hatano M, Matsumoto S.
• PLoS One. 10, e0141658, 2015

Myeloid HIF-1 attenuates the progression of renal fibrosis in murine obstructive nephropathy.

• Tateishi Y, Osada-Oka M, Tanaka M, Shiota M, Izumi Y, Ishimura E, Motoyama K, Inaba M, Miura K.
• J Pharmacol Sci. 127, 181-189, 2015

Repeated remote ischemic conditioning attenuates left ventricular remodeling via exosome-mediated intercellular communication on chronic heart failure after myocardial infarction.

• Yamaguchi T, Izumi Y, Nakamura Y, Yamazaki T, Shiota M, Sano S, Tanaka M, Osada-Oka M, Shimada K, Miura K, Yoshiyama M, Iwao H.
• Int J Cardiol. 178, 239-46, 2015

Percutaneous carbon dioxide treatment using a gas mist generator enhances collateral blood flow of ischemic hindlimb.

• Izumi Y, Yamaguchi T, Yamazaki T, Yamashita N, Nakamura Y, Shiota M, Tanaka M, Sano S, Osada-Oka M, Shimada K, Wanibuchi H, Miura K, Yoshiyama M, Iwao H.
• J Arterioscler Thromb. 22, 38-51, 2015

Therapeutic administration of an ingredient of aged-garlic extracts, S-allyl cysteine resolves liver fibrosis established by carbon tetrachloride in rats.

• Kodai S, Takemura S, Kubo S, Azuma H, Minamiyama Y.
• J Clin Biochem Nutr. 2015 May;56(3):179-85. doi: 10.3164/jcbn.14-108.

A mitochondrial superoxide theory for oxidative stress diseases and aging.

• Indo HP, Yen HC, Nakanishi I, Matsumoto K, Tamura M, Nagano Y, Matsui H, Gusev O, Cornette R, Okuda T, Minamiyama Y, Ichikawa H, Suenaga S, Oki M, Sato T, Ozawa T, Clair DK, Majima HJ.
• J Clin Biochem Nutr. 2015 Jan;56(1):1-7. doi: 10.3164/jcbn.14-42.

S-allyl cysteine ameliorates the quality of sperm and provides protection from age-related sperm dysfunction and oxidative stress in rats.

• Takemura S, Ichikawa H, Naito Y, Takagi T, Yoshikawa T, Minamiyama Y.
• J Clin Biochem Nutr. 2014 Nov;55(3):155-61. doi: 10.3164/jcbn.14-39. Epub 2014 Oct 21.

Noninvasive metabolic syndrome model using an extremely small minipig, the microminipig.

• Yamaguchi T, Yamazaki T, Kawaguchi H, Tawa M, Nakamura Y, Shiota M, Osada-Oka M, Tanimoto A, Okamura T, Miura K, Iwao H, Yoshiyama M, Izumi Y.
• J Pharmacol Sci. 126, 168-71, 2014

Establishment of neutralizing rat monoclonal antibodies for fibroblast growth factor-2.

• Tanaka M, Yamaguchi M, Shiota M, Kawamoto Y, Takahashi K, Inagaki A, Osada-Oka M, Harada A, Wanibuchi H, Izumi Y, Miura K, Iwao H, Ohkawa Y.
• Monoclon Antib Immunodiagn Immunother. 33, 261-9, 2014

Serological surveillance development for tropical infectious diseases using simultaneous microsphere-based multiplex assays and finite mixture models.

• Fujii Y, Kaneko S, Nzou SM, Mwau M, Njenga SM, Tanigawa C, Kimotho J, Mwangi AW, Kiche I, Matsumoto S, Niki M, Osada-Oka M, Ichinose Y, Inoue M, Itoh M, Tachibana H, Ishii K, Tsuboi T, Yoshida LM, Mondal D, Haque R, Hamano S, Changoma M, Hoshi T, Kamo K, Karama M, Miura M, Hirayama K.
• PLoS Negl Trop Dis. 8, e3040, 2014

Hsc70 contributes to cancer cell survival by preventing Rab1A degradation under stress conditions.

• Tanaka M, Mun S, Harada A, Ohkawa Y, Inagaki A, Sano S, Takahashi K, Izumi Y, Osada-Oka M, Wanibuchi H, Yamagata M, Yukimura T, Miura K, Shiota M, Iwao H.
• PLoS One. 9, e96785, 2014

Lipid synthesis is promoted by hypoxic adipocyte-derived exosomes in 3T3-L1 cells.

• Sano S, Izumi Y, Yamaguchi T, Yamazaki T, Tanaka M, Shiota M, Osada-Oka M,　Nakamura Y, Wei M, Wanibuchi H, Iwao H, Yoshiyama M.
• Biochem Biophys Res Commun. 445, 327-333, 2014

S-allyl cysteine improves nonalcoholic fatty liver disease in type 2 diabetes Otsuka Long-Evans Tokushima Fatty rats via regulation of hepatic lipogenesis and glucose metabolism.

• Takemura S,　Minamiyama Y, Kodai S, Shinkawa H, Tsukioka T, Okada S, Azuma H, Kubo S.
• J. Clin. Biol. Nutr. (2013)

Comparison of in vivo and in vitro antioxidative parameters for eleven food factors.

• Indo HP, Nakanishi I, Ohkubo K, Hsiu-Chuan Yen, Nyui M, Manda S, Matsumoto K, Fukuhara K, Anzai K, Ikota N, Matsui H,　Minamiyama Y, Nakajima A, Ichikawa H, Fukuzumi S, Ozawa T, Mukai C, and Majima HJ.
• The Royal Society of Chemistry 3:4535-4538(2013)

Multicolor Flow cytometric analyses of CD4+ T cell responses to Mycobacterium tuberculosis-related latent antigens.

• Yamashita Y, Hoshino Y, Oka M, Matsumoto S, Ariga H, Nagai H, Makino M, Ariyoshi K, Tsunetsugu-Yokota Y.
• Jpn J Infect Dis. 66, 207-215, 2013

Tolvaptan attenuates left ventricular fibrosis after acute myocardial infarction in rats.

• Yamazaki T, Nakamura Y, Shiota M, Osada-Oka M, Fujiki H, Hanatani A, Shimada K, Miura K, Yoshiyama M, Iwao H, Izumi Y.
• J Pharmacol Sci. 123, 58-66, 2013

Antigen 85A and mycobacterial DNA-binding protein 1 are targets of immunoglobulin G in individuals with past tuberculosis.

• Osada-Oka M, Tateishi Y, Hirayama Y, Ozeki Y, Niki M, Kitada S, Maekura R,　Tsujimura K, Koide Y, Ohara N, Yamamoto T, Kobayashi K, Matsumoto S.
• Microbiol Immunol. 2013 Jan;57(1):30-7.

Biomarker for Diagnosis of Mycobacterium tuberculosis Infection.

• Osada-Oka M, Ozeki Y, Matsumoto S, Iwao H
• 大阪市医学会誌　第61巻（3・4） 2012

Suppression of indomethacin-induced apoptosis in the small intestine due to Bach1 deficiency.

• Harusato A, Naito Y, Takagi T, Uchiyama K, Mizushima K, Hirai Y, Yamada S, Tuji T, Yoriki H, Horie R, Inoue K, Fukumoto K, Handa O, Ishikawa T, Kokura S,Minamiyama Y, Ichikawa H, Muto A, Igarashi K, Yoshikawa T.
• Free Radic Res. 45(6):717-27 (2011)

Generation of reactive oxygen species in sperms of rats as an earlier marker for evaluating the toxicity of endocrine-disrupting chemicals.

• Minamiyama Y, Ichikawa H, Takemura S, Kusunoki H, Naito Y, Yoshikawa T.　
• Free Radic Res. 44(12):1398-406 (2010)

Coadministration of carvedilol attenuates nitrate tolerance by preventing cytochrome p450 depletion.

• Nakahira A,Minamiyama Y, Takemura S, Hirai H, Sasaki Y, Okada S, Funae Y, Suehiro S.
• Circ J. Aug;74(8):1711-7 (2010)

Iron restriction improves type II diabetes mellitus of Otsuka Long-Evans Tokushima Fatty (OLETF) rats via inhibition of endogenously reactive oxygen species and the regulation of pancreas peroxisome proliferator–activated receptor-delta (PPAR-delta) and hypoxia inducible factor (HIF)-1alpha.

• Minamiyama Y, Takemura S, Kodai S, Shinkawa H, Tsukioka T, Naito Y, Ichikawa H, Yoshikawa T, Okada S.
• Am J Physiol 298(6):E1140-9 (2010)

S-allylcysteine is effective as a chemopreventive agent against porcine serum-induced hepatic fibrosis in rats.

• Shinkawa H, Takemura S,Minamiyama Y, Kodai S, Tsukioka T, Oka OM, Kubo S, Okada S, Suehiro S.
• Osaka City Med J 51: 61-69 (2009)

岡田茂，南山幸子. 酸化ストレスとAOB

• マイクロ出版, 岡山, (2009)
• 第２版, マイクロ出版, 岡山, (2011)

その他刊行物

• 南山幸子「ヘルシーエイジングを目指して」―若さを保つための食生活―環境と健康28：366－372(2015)
• 南山幸子，吉川敏一. 「健康ガイド」アンチエイジング, 京都女性新聞　2009.3.1号
• 南山幸子，竹村茂一，新川寛二，市川寛，内藤裕二，吉川敏一、岡田茂. α-トコフェロールは 2型糖尿病ラットの治療に有効である (γ-トコフェロールとの比較), ビタミンE研究の進歩XIV: pp. 77-80 (2010), ビタミンＥ研究会編 共立出版(東京)
• 南山幸子　アンチエイジング・ヘルシーエイジングのための生活習慣,SKY冬号 22-23 (2010), 京都SKYセンター
• 南山幸子　特集「知りたい体の疑問」HBR 11月号　pp.14-15 (2010),　講談社
• 南山幸子、竹村茂一、中平敦士、冨永敦子、佐々木康之、平井秀和、細野光治、末廣茂文　ニコランジルはNO非依存性にcGMPを酸性紙、チトクロームP450の低下や硝酸剤耐性を起こさない 34巻 315-323, Therapeutic Research
• 総説
• 南山幸子，吉川敏一. アンチエイジングとは, 環境と健康22: 296-304 (2009)
• 南山幸子，吉川敏一. イチョウ葉エキス, Functional Food９:220-225 (2010),　フジメディカル出版
• 南山幸子、井上正康、活性酸素代謝制御御試薬.活性酸素とシグナル伝達　レドソックス制御と生物の生存戦略,　井上正康編,　講談社：201－215(1996)

その他

招待講演

• 第１１回日本抗加齢医学会総会　シンポジウム１２「何をどう食べるかの科学」
• 現代社会における安全・安心な食べ物〜食性病害のない食品とは　2011.5.28 (京都)

特許

• 金ナノコロイド水による好中球の機能制限方法，好中球の機能制限用金ナノコロイド水，金ナノコロイド水を用いた飲料および食品　（特開2011-111442）
• 白血球活性化抑制剤　(特願2011-172116)

受賞
　　　　平成13年5月　第5回日本フリーラジカル学会奨励賞
　　　　平成18年2月　大阪市医学会市長賞